Micro-CT在拔牙后位点保存动物模型中的应用

doi:10.13701/j.cnki.kqyxyj.2025.09.002

摘要/Abstract

摘要： 拔牙后牙槽嵴高度和宽度的维持和再生直接影响种植修复效果, 显微计算机断层扫描(micro computed tomography,Micro-CT /μ-CT)技术因其分辨率高、可三维成像和定量分析等优势,成为评估位点保存效果的重要影像学测量工具。但由于动物模型选择、系统程序应用、图像采集方法、图像评估和定量分析方式差异大这一研究现状,使读者难以系统、定量、科学地比较分析各类手术方案或骨再生材料在不同研究中的修复效果与参数,导致难以依据文献结果得出最佳决策。因此,本文在Micro-CT成像系统的组成和工作原理、动物模型选择的基础上,综述了Micro-CT 在拔牙后位点保存动物模型研究中的样本的放置与固定、图像采集设备参数选择、感兴趣区圈画方式、常规与特异性定量指标意义和选择考量方式,并总结技术未来发展方向和挑战,以期推动Micro-CT技术在牙槽骨保存研究中的标准形成,提高数据分析的准确性、可重复性和可比性。

关键词: Micro-CT, 位点保存, 动物模型, 定量分析, 牙槽骨缺损

Abstract: Maintaining and regenerating alveolar bone height and width after tooth extraction directly affect the effect of implant restoration. Micro computed tomography (Micro-CT) technology, with its high resolution, three-dimensional imaging, and quantitative analysis, is a key tool for evaluating site preservation. However, due to the variety in animal models, programs, image acquisition methods, and analysis methods, it is hard to compare the effectiveness of different surgeries or bone regeneration materials. This leads to challenges in making optimal decisions from current research findings. This article reviews the placement and fixation of samples, selection of device parameters, region of interest delineation, significance and selection quantitative indicators in post-extraction site of preservation animal models, based on the composition and working principles of the Micro-CT imaging system and the selection of animal models. It also summarizes the direction of future technological developments and challenges, aiming to promote the standardization of Micro-CT technology in alveolar bone preservation research and improve the accuracy, repeatability, and comparability of data analysis.

Key words: Micro-CT, site preservation, animal model, quantitative analysis, alveolar bone defect

杨志康, 姜雨汐. Micro-CT在拔牙后位点保存动物模型中的应用[J]. 口腔医学研究, 2025, 41(9): 743-749.

YANG Zhikang, JIANG Yuxi. Application of Micro-CT in Animal Model of Site Preservation after Tooth Extraction[J]. Journal of Oral Science Research, 2025, 41(9): 743-749.

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