激活转录因子家族在口腔疾病及牙发育中的研究进展

doi:10.13701/j.cnki.kqyxyj.2025.11.003

摘要/Abstract

摘要： 口腔疾病是全球流行疾病之一,严重影响人们的口腔健康、功能和美观。激活转录因子(activating transcription factors, ATFs)家族属于bZIP类转录因子家族,包括ATF1、ATF2、ATF3、ATF4、ATF5、ATF6和ATF7,参与细胞增殖、迁移、侵袭、凋亡和分化等过程。近年来,有研究显示ATFs在口腔发育、再生、炎症和肿瘤中发挥重要作用。然而,关于ATFs家族在口腔疾病中的研究进展综述鲜见报道,且ATFs在口腔疾病及牙发育中的作用机制尚未充分阐明。因此,本文对ATFs在口腔疾病和牙发育中的作用进行总结,为深入研究ATFs在口腔疾病中的作用机制提供参考。

关键词: 激活转录因子, 口腔疾病, 作用机制

Abstract: Oral pathologies are one of the most prevalent diseases globally, severely affecting oral health, function, and aesthetics. The activating transcription factors (ATFs) family belongs to the bZIP transcription factor superfamily, including ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, and ATF7, and is involved in processes such as cell proliferation, migration, invasion, apoptosis, and differentiation. In recent years, studies have highlighted the functional significance of ATFs in oral development, tissue regeneration, inflammation, and tumorigenesis. However, comprehensive reviews summarizing recent advances on the ATFs family in oral pathologies remain scarce, and the molecular mechanisms governing their regulatory roles in both stomatological disorders and odontogenesis are not yet fully elucidated. Therefore, a systematic review of ATFs-mediated regulatory mechanisms in oral pathologies and odontogenesis would provide critical insights into the molecular mechanisms of ATFs-associated processes in stomatological disorders.

Key words: activating transcription factors, oral pathologies, molecular mechanisms

田珂, 唐静. 激活转录因子家族在口腔疾病及牙发育中的研究进展[J]. 口腔医学研究, 2025, 41(11): 941-945.

TIAN Ke, TANG Jing. Research Progress of ATFs Family in Oral Pathologies and Odontogenesis[J]. Journal of Oral Science Research, 2025, 41(11): 941-945.

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