氟化亚锡联合超顺磁氧化纳米铁促进牙釉质再矿化的体外研究

doi:10.13701/j.cnki.kqyxyj.2026.02.007

口腔医学研究 ›› 2026, Vol. 42 ›› Issue (2): 121-125.DOI: 10.13701/j.cnki.kqyxyj.2026.02.007

氟化亚锡联合超顺磁氧化纳米铁促进牙釉质再矿化的体外研究

李节龙, 霍风莉, 齐芳芳, 赵子晗, 董浩然, 陈瑞雪^*

河北医科大学口腔医学院,河北省医科大学口腔医院,牙体牙髓科教研室,河北省口腔医学重点实验室,河北省口腔健康技术创新中心河北石家庄 050017

收稿日期:2025-05-12 发布日期:2026-02-28
通讯作者: *陈瑞雪,E-mail:crxzxd@hebmu.edu.com
作者简介:李节龙(2000~ ),男,山东聊城人,硕士,研究方向:口腔内科学。
基金资助:
河北省财政厅政府资助临床医学优秀人才项目(编号:361029); 河北医科大学大学生创新性实验计划项目(编号:USIP2024250)

In Vitro Study on Promotion of Enamel Re-mineralization by Tin (Ⅱ) Fluoride (SnF₂) Combined with Ferumoxytol

LI Jielong, HUO Fengli, QI Fangfang, ZHAO Zihan, DONG Haoran, CHEN Ruixue^*

Department of Cariology and Endodontics, Hebei Key Laboratory of Stomatology, Hebei Technology Innovation Center of Oral Health, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang 050017, China

Received:2025-05-12 Published:2026-02-28

摘要/Abstract

摘要： 目的: 探究氟化亚锡联合超顺磁氧化纳米铁应用于脱矿的离体牙釉质促进其再矿化的作用。方法: 制备80片符合标准的牙釉质片,浸泡于脱矿液中模拟人体口腔内的牙体组织脱矿过程,脱矿后分为实验组和对照组,实验组分为氟化钠组、氟化亚锡组、不同浓度的氟化亚锡联合超顺磁氧化纳米铁组,对照组使用去离子水浸泡,浸泡结束后分别测量其显微硬度,进行扫描电镜观测并进行质谱分析。结果: 100 PPM氟化亚锡联合超顺磁氧化纳米铁溶液组的再矿化效果与250 PPM氟化钠溶液组基本相同。结论: 100 PPM氟化亚锡联合超顺磁氧化纳米铁溶液有效降低了氟制剂的使用浓度,并且使氟化亚锡的水溶液变得稳定。

关键词: 脱矿, 再矿化, 氟化钠, 氟化亚锡, 超顺磁氧化纳米铁

Abstract: Objective: To investigate the role of SnF₂ in combination with ferumoxytol in promoting the remineralization of demineralized enamel of isolated teeth. Methods: Eighty enamel slices that met the standards were prepared and immersed in demineralization solution to simulate the demineralization process of dental tissues in the human oral cavity. After demineralization, they were divided into experimental and control groups. The experimental group was further divided into sodium fluoride (NaF) group, SnF₂ group, and different concentrations of SnF₂ combined with ferumoxytol group. The control group was immersed in deionized water. After the immersion, their microhardness was measured respectively, and scanning electron microscopy observation and mass spectrometry analysis were carried out. Results: The remineralization effect of the 100 PPM SnF₂ combined with ferumoxytol solution group was basically the same as that of the 250 PPM SnF₂ solution group. Conclusion: 100 PPM SnF₂ combined with ferumoxytol solution effectively reduces the usage concentration of fluorine preparations and makes the aqueous solution of SnF₂ fluoride stable.

Key words: demineralization, remineralization, sodium fluoride, tin (Ⅱ) fluoride, ferumoxytol

李节龙, 霍风莉, 齐芳芳, 赵子晗, 董浩然, 陈瑞雪. 氟化亚锡联合超顺磁氧化纳米铁促进牙釉质再矿化的体外研究[J]. 口腔医学研究, 2026, 42(2): 121-125.

LI Jielong, HUO Fengli, QI Fangfang, ZHAO Zihan, DONG Haoran, CHEN Ruixue. In Vitro Study on Promotion of Enamel Re-mineralization by Tin (Ⅱ) Fluoride (SnF₂) Combined with Ferumoxytol[J]. Journal of Oral Science Research, 2026, 42(2): 121-125.

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氟化亚锡联合超顺磁氧化纳米铁促进牙釉质再矿化的体外研究

In Vitro Study on Promotion of Enamel Re-mineralization by Tin (Ⅱ) Fluoride (SnF₂) Combined with Ferumoxytol

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氟化亚锡联合超顺磁氧化纳米铁促进牙釉质再矿化的体外研究

In Vitro Study on Promotion of Enamel Re-mineralization by Tin (Ⅱ) Fluoride (SnF2) Combined with Ferumoxytol

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In Vitro Study on Promotion of Enamel Re-mineralization by Tin (Ⅱ) Fluoride (SnF₂) Combined with Ferumoxytol