IGF-1R与IGFBP-3在口腔鳞状细胞癌中的表达及其临床意义

口腔医学研究 ›› 2015, Vol. 31 ›› Issue (10): 1000-1003.

IGF-1R与IGFBP-3在口腔鳞状细胞癌中的表达及其临床意义

金成学¹,李明贺¹,岳丽伟²,张茹慧^1*

1. 吉林大学口腔医学院颌面外科吉林长春 130021;
2. 吉林省伊通县第一人民医院口腔科吉林伊通 130700

收稿日期:2015-03-30 出版日期:2015-10-28 发布日期:2016-05-04
通讯作者: 张茹慧,E-mail:591131713.qq.com
作者简介:金成学(1988~ ) ,男,朝鲜族,吉林人,硕士,医师,主要从事口腔颌面外科临床及基础的研究工作。
基金资助:
吉林省产业技术研究开发项目(编号:2013.779)

Expression and Clinical Significance of IGF-1R and IGFBP-3 in Oral Squamous Cell Carcinoma

JIN Cheng-xue¹, LI Ming-he¹, YUE Li-wei², ZHANG Ru-hui¹

1. Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun 130021, China;
2. Department of Stomatology, First People's Hospital, Yitong 130700, China

Received:2015-03-30 Online:2015-10-28 Published:2016-05-04

摘要/Abstract

摘要： 目的:检测IGF-1R与IGFBP-3在口腔鳞状细胞癌(Oral squamous cell carcinoma, OSCC)组织中的表达,探讨其在OSCC病变中的作用及其临床意义。方法:应用免疫组织化学法(SP法)检测66例OSCC、20例癌旁组织及50例正常的口腔黏膜组织中IGF-1R与IGFBP-3的表达,数据采用SPSS19.0统计软件进行。结果:IGF-1R与IGFBP-3在OSCC组织、癌旁组织及正常组织中的阳性表达率均依次减低,均有显著性差异(P＜0.05)。两种蛋白在OSCC中表达呈负相关(P＜0.05)。结论:IGF-1R与IGFBP-3的表达与OSCC的病理分级和临床发展关系密切。

关键词: 鳞状细胞癌, IGF-1R蛋白, IGFBP-3蛋白, 免疫组织化学

Abstract: Objective: To detect the expression of IGF-1R and IGFBP-3 in oral squamous cell carcinoma (OSCC), and explore its clinical and pathological significance. Methods: The expression levels of IGF-1R and IGFBP-3 in 66 cases of OSCC, 20 cases of adjacent tissues of OSCC and 50 cases of normal oral mucosa tissues were detected by immunohistochemistry of S-P staining. The data was statistically analyzed by SPSS19.0. Results: The expression of IGF-1R and IGFBP-3 in OSCC group, adjacent tissue of OSCC and normal group was successively decreased and significantly different (P＜0.05). The expression of IGF-1R and IGFBP-3 was negatively correlated in OSCC tissues (P<0.05). Conclusion: There were significant correlations between the expression of IGF-1R, IGFBP-3 and clinical and pathological features of OSCC.

Key words: Oral squamous cell carcinoma, IGF-1R, IGFBP-3, Immunohistochemistry

中图分类号:

R739.8

金成学,李明贺,岳丽伟,张茹慧. IGF-1R与IGFBP-3在口腔鳞状细胞癌中的表达及其临床意义[J]. 口腔医学研究, 2015, 31(10): 1000-1003.

JIN Cheng-xue, LI Ming-he, YUE Li-wei, ZHANG Ru-hui. Expression and Clinical Significance of IGF-1R and IGFBP-3 in Oral Squamous Cell Carcinoma[J]. Journal of Oral Science Research, 2015, 31(10): 1000-1003.

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