口腔医学研究

口腔医学研究 ›› 2015, Vol. 31 ›› Issue (10): 995-999.

• 临床研究论著 • 上一篇    下一篇

新疆墨玉县维吾尔族成人慢性牙周炎与维生素D受体基因多态性的相关性研究

吴龙,林静,王东麟,赵今*   

  1. 新疆医科大学第一附属医院牙体牙髓科;新疆维吾尔自治区口腔医学研究所 新疆 乌鲁木齐 830054
  • 收稿日期:2015-03-10 出版日期:2015-10-28 发布日期:2016-05-04
  • 通讯作者: 赵今,E-mail: merryljin@sina.com
  • 作者简介:吴龙(1988~ ),男,宁夏人,硕士,住院医师,主要从事牙周疾病的防治研究。
  • 基金资助:
    中华口腔医学会西部行口腔医学临床科研基金(编号:CSA-W2014-01)

Association between Chronic Periodontitis and Vitamin D Receptor Gene Polymorphisms among Uygur Adults in Moyu County of Xinjiang

WU Long, LIN Jing, WANG Dong-lin, ZHAO Jin*   

  1. Department of Dentistry and Endodontics, the First Affiliated Hospital of Xinjiang Medical University, Research Institute of Dentistry of Xinjiang Uygur Autonomous Resion, Urumqi 830054, China
  • Received:2015-03-10 Online:2015-10-28 Published:2016-05-04

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摘要： 目的:探讨维生素D受体(vitamin D receptor, VDR)基因BsmI、TaqI位点单核苷酸多态性(Single Nucleotide Polymorphisms, SNP)与新疆墨玉县维吾尔族成人慢性牙周炎(chronic periodontitis, CP)的相关性。方法:选取2013年3~4月课题组对新疆墨玉县维吾尔族进行的流行病学调查资料及采集的颊黏膜拭子样本,共纳入185例个体,包括CP患者95例和健康对照者90例,采用聚合酶链式反应-限制性片段长度多态性(polymerase chain reaction-restriction fragment length polymorphism, PCR-RFLP)方法测定BsmI、TaqI位点基因型,探讨VDR基因多态性与CP的相关性。结果:对照组和CP组在BsmI位点的基因型分布有显著性差异,等位基因频率的分布亦有显著性差异(P=0.016,P=0.003);在TaqI位点两组间的基因型和等位基因频率的分布差异均无统计学意义(P=0.582,P=0.606);在男性和女性研究对象中两组间仅BsmI位点等位基因频率的分布差异有统计学意义(P=0.025,P=0.042);单因素logistic回归分析显示bb基因型和等位基因b可能是CP的易感因子。结论:新疆墨玉县维吾尔族成人慢性牙周炎的易感性可能与VDR基因BsmI位点相关,bb基因型和等位基因b可能是维吾尔族成人CP的易感因子。

关键词: 慢性牙周炎, 维生素D受体, 基因多态性, 维吾尔族

Abstract: Objective: To investigate the association between Vitamin D receptor (VDR) gene BsmI and TaqI polymorphisms and chronic periodontitis (CP) among Uygur adults in Moyu County of Xinjiang. Methods: The buccal swabs of 185 subjects, including 95 CP patients and 90 healthy controls, were randomly selected from epidemiological investigation of Uygur adults in Moyu County from March to April 2013. VDR BsmI and TaqI were tested with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to investigate the association between VDR gene polymorphism and CP. Results: There was statistically significant difference in the frequencies of VDR BsmI genotypes and alleles between the CP patients and healthy controls (P=0.016,P=0.003). There was no statistically significant difference in the frequencies of VDR TaqI genotypes and alleles between two groups. Chronic periodontitis and healthy controls only show significant difference in VDR BsmI allele frequencies in male and female. One way logistic analysis showed that bb genotype and allele b might be the risk factors of CP. Conclusion: The susceptibility to chronic periodontitis among Uygur adults in Moyu County of Xinjiang is related to the BsmI polymorphism of VDR gene, the bb genotype and allele b may be the risk factors of CP in Uygur adults.

Key words: Chronic periodontitis, Vitamin D receptor, Genetic polymorphism, Uygur nationality

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