MicroRNA-7与肿瘤关系研究进展及在口腔肿瘤中的展望

口腔医学研究 ›› 2015, Vol. 31 ›› Issue (12): 1261-1263.

MicroRNA-7与肿瘤关系研究进展及在口腔肿瘤中的展望

郭拴龙,张斌^*,李莹^*

哈尔滨医科大学附属第二医院,哈尔滨医科大学中俄医学研究中心硬组织发育与再生研究所黑龙江哈尔滨 150086

收稿日期:2014-07-18 出版日期:2015-12-28 发布日期:2016-03-21
通讯作者: 张斌,E-mail:zhangbhyd@126.com
李莹,E-mail:Bonnieli1122@gomail.com
作者简介:郭拴龙(1988~),男,山西人,硕士在读,主要从事口腔肿瘤方面的研究工作。
基金资助:
国家自然科学基金项目(编号:81170960)

Research Progress on Relationship between MicroRNA-7 and Tumor and Prospect of Its Application in Oral Malignant Tumors.

GUO Shuan-long, ZHANG Bin, LI Ying.

Sino-Russian Institute of Hard Tissue Development and Regeneration, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China

Received:2014-07-18 Online:2015-12-28 Published:2016-03-21

摘要/Abstract

摘要： MicroRNAs是具有调控基因表达功能的非编码小分子单链RNA,长度约为 21~25 个核苷酸, 在癌症以及其他疾病的发生、发展中发挥着重要的作用。最近的研究发现MicroRNA-7在多种肿瘤细胞中表达异常,而将人工合成的MicroRNA-7导入肿瘤细胞可以明显影响其细胞增殖、侵袭、转移能力。本文就MicroRNA-7在多种肿瘤的研究进展做一综述,并对其在口腔恶性肿瘤中的应用作一展望。

关键词: MicroRNA-7, 肿瘤, 口腔, 治疗

Abstract: MicroRNAs are small and noncoding RNAs with regulatory functions, about 21 to 25 nucleotides, which play an important role in many human diseases, including cancer. Recent studies indicate that abnormal expression of MicroRNA-7 exists in a wide variety of tumor cells, and the cell proliferation, invasion and metastasis ability changed after introducing manual MicroRNA-7 into tumor cells. In this paper, advances in the research of MicroRNA-7 in tumors are summarized, and reasonable prospect is presented on its application in oral and maxillofacial malignant tumor.

中图分类号:

R739.8

郭拴龙,张斌,李莹. MicroRNA-7与肿瘤关系研究进展及在口腔肿瘤中的展望[J]. 口腔医学研究, 2015, 31(12): 1261-1263.

GUO Shuan-long, ZHANG Bin, LI Ying.. Research Progress on Relationship between MicroRNA-7 and Tumor and Prospect of Its Application in Oral Malignant Tumors.[J]. Journal of Oral Science Research, 2015, 31(12): 1261-1263.

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