Pinx1 在口腔鳞癌中的表达及意义

doi:10.13701/j.cnki.kqyxyj.2016.10.015

口腔医学研究 ›› 2016, Vol. 32 ›› Issue (10): 1064-1066.DOI: 10.13701/j.cnki.kqyxyj.2016.10.015

Pinx1 在口腔鳞癌中的表达及意义

吕珊珊¹, 魏秀峰^1*, 孙鑫¹, 周阳¹, 魏玉雪², 刘桐¹, 高旭¹

1.吉林大学口腔医学院口腔黏膜病科,吉林省牙发育及颌骨重塑与再生重点实验室吉林长春 130021;
2. 吉林大学口腔医学院口腔修复科吉林长春 130021

收稿日期:2016-03-23 出版日期:2016-10-26 发布日期:2016-10-26
通讯作者: 魏秀峰,E-mail:xfw79@sina.com
作者简介:吕珊珊(1989~ ),女,山东省青岛市人,硕士在读,主要从事口腔黏膜病基础与临床方面的研究。
基金资助:
吉林省科技厅资助课题(编号:20160101052JC)

Expression and Significance of Pinx1 in Oral Squamous Cell Carcinoma.

LV Shan-shan¹, WEI Xiu-feng^1,*, SUN Xin¹, ZHOU Yang¹, WEI Yu-xue², LIU Tong¹, GAO Xu¹.

1. Department of Oral Medicine and Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School and Hospital of Stomatology, Jilin University, Changchun 130021, China;
2. Department of Prosthodontics, School and Hospital of Stomatology, Jilin University, Changchun 130021, China.

Received:2016-03-23 Online:2016-10-26 Published:2016-10-26

摘要/Abstract

摘要： 目的:研究Pinx1在口腔鳞状细胞癌(OSCC)中的表达及意义。方法:免疫组织化学染色检测Pinx1在60例OSCC和20例正常口腔黏膜组织(NOM)中的表达情况。结果:Pinx1在NOM上皮中高表达,高表达率为100.00%,在OSCC中高表达率为65.00%,Pinx1高表达率明显低于NOM(P＜0.05),随着分化程度的降低,Pinx1表达呈降低趋势(P＜0.05),伴有淋巴结转移的病例中Pinx1表达水平显著低于不伴有淋巴结转移的OSCC(P＜0.05),Pinx1的表达情况与患者性别年龄无关。结论:Pinx1可能与OSCC的发生、发展及转移有关。

关键词: Pinx1, 口腔鳞状细胞癌, 免疫组织化学

Abstract: Objective: To explore the expression and significance of Pinx1 in oral squamous cell carcinoma (OSCC). Methods: The expression of Pinx1 in 60 cases of OSCC and 20 cases of normal oral mucosa (NOM) was detected by immunohistochemistry. Results: The high expression of Pinx1 in the NOM epithelium was detected, and the positive rate was 100%. By contrast, the expression and positive rate (65%) of Pinx1 was significantly decreased in OSCC (P<0.05). With the increase of malignant degree, PinX1 expression showed a decreased trend (P<0.05). In addition, PinX1 expression level was significantly lower in OSCC patients with lymph node metastasis than those without lymph node metastasis (P<0.05). The expression of Pinx1 was not correlated with the gender and age of OSCC patients.Conclusion: Pinx1 may be related to the occurrence, development and metastasis of OSCC.

Key words: Pinx1, Oral squamous cell carcinoma, Immunohistochemistry

中图分类号:

R739.8

吕珊珊, 魏秀峰, 孙鑫, 周阳, 魏玉雪, 刘桐, 高旭. Pinx1 在口腔鳞癌中的表达及意义[J]. 口腔医学研究, 2016, 32(10): 1064-1066.

LV Shan-shan, WEI Xiu-feng, SUN Xin, ZHOU Yang, WEI Yu-xue, LIU Tong, GAO Xu.. Expression and Significance of Pinx1 in Oral Squamous Cell Carcinoma.[J]. Journal of Oral Science Research, 2016, 32(10): 1064-1066.

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Pinx1 在口腔鳞癌中的表达及意义

Expression and Significance of Pinx1 in Oral Squamous Cell Carcinoma.

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