自噬在骨组织疾病中的调控作用研究进展

doi:10.13701/j.cnki.kqyxyj.2017.05.026

口腔医学研究 ›› 2017, Vol. 33 ›› Issue (5): 571-573.DOI: 10.13701/j.cnki.kqyxyj.2017.05.026

自噬在骨组织疾病中的调控作用研究进展

顾中一¹,费鸿博¹,李洋洋¹,徐晓薇¹,孙宏晨²,林崇韬^1*

(1. 吉林大学口腔医院牙周科吉林长春 130021;2. 吉林大学口腔医学病理科吉林长春 130021)

收稿日期:2016-05-18 出版日期:2017-05-20 发布日期:2017-05-26
作者简介:顾中一(1991~ ),男,山东人,硕士在读,主要从事牙周病的研究工作。
基金资助:
国家自然科学基金面上项目资助项目 (编号:81371153)
吉林省科技厅自然科学基金(编号:20120101173JC)

Research Progress of the Regulatory Role of Autophagy in Bone Diseases.

GU Zhong-yi¹, FEI Hong-bo¹, LI Yang-yang¹, XU Xiao-wei¹, SUN Hong-chen², LIN Chong-tao^1*.

1. Department of Periodontology, School of Stomatology, Jilin Univerisity. Changchun 130021, China; 2. Department of Pathology, School of Stomatology, Jilin Univerisity. Changchun 130021, China.

Received:2016-05-18 Online:2017-05-20 Published:2017-05-26

摘要/Abstract

摘要： 骨是一种动态活性组织,通过持续的骨重塑维持矿化平衡和自身结构稳定。而自噬是细胞依赖溶酶体进行自体溶解的过程,对骨组织细胞功能具有重要作用,自噬平衡的打破与骨类疾病发生发展密不可分。因此,全面认识自噬对骨组织的调控作用具有重要理论意义和实际应用价值。本文就自噬的形成、自噬与骨组织细胞的作用机制及自噬在骨组织疾病发生发展中的调控机制做一综述,为进一步探讨通过调控自噬治疗骨类疾病提供指导。

关键词: 自噬, 骨组织细胞, 骨类疾病, 调控机制

Abstract: Bone is a kind of dynamic active tissue, which could maintain mineralization balance and self-structure stability by sustaining bone remodeling. Autophagy is a process of self-lysis depending on the cells' lysosomal which plays an important role in the function of bone cells. The breaking of the autophagy balance is closely related to the development of bone diseases. Therefore, it is of great theoretical significance and practical value to fully understand the role of autophagy in the regulation of bone tissues. Thus, in this paper, the formation of the autophapy, the relationship between of the autophagy and the bone cells and the mechanism of autophagy in bone diseases are reviewed as well, in order to further explore the regulation of autophagy during the treatments about bone diseases.

中图分类号:

Q132

顾中一,费鸿博,李洋洋,徐晓薇,孙宏晨,林崇韬. 自噬在骨组织疾病中的调控作用研究进展[J]. 口腔医学研究, 2017, 33(5): 571-573.

GU Zhong-yi, FEI Hong-bo, LI Yang-yang, XU Xiao-wei, SUN Hong-chen, LIN Chong-tao.. Research Progress of the Regulatory Role of Autophagy in Bone Diseases.[J]. Journal of Oral Science Research, 2017, 33(5): 571-573.

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自噬在骨组织疾病中的调控作用研究进展

Research Progress of the Regulatory Role of Autophagy in Bone Diseases.

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