牙周膜干细胞表观遗传学研究进展

doi:10.13701/j.cnki.kqyxyj.2021.11.005

摘要/Abstract

摘要： 牙周膜干细胞(periodontal ligament stem cells, PDLSCs)是牙周膜组织中的间充质干细胞,是牙周组织再生和修复的重要细胞群,牙周微环境的变化会影响牙周膜干细胞的生物学特性。表观遗传(epigenetics)是指不基于DNA序列的变化,而出现稳定可遗传的基因表达水平及功能的改变。环境因素是影响表观遗传的重要因素之一,暴露环境的不同可以引起表观修饰改变,进而影响基因表达。表观遗传是干细胞生物学特性的重要内源性调控机制,在干细胞中的变化稳定可遗传,并具有可逆性。近年来牙周膜干细胞的表观遗传调控已成为研究热点,本文通过对表观遗传调控对牙周膜干细胞生物学特性的影响进行综述,以期使牙周膜干细胞更好地应用于牙周再生修复。

关键词: 表观遗传学, 牙周膜干细胞, DNA甲基化, 组蛋白修饰, 非编码RNA调控

Abstract: Periodontal ligament stem cells (PDLSCs) are mesenchymal stem cells in periodontal ligament tissue, which are important cell group for periodontal tissue regeneration and repair. Changes of periodontal microenvironment will affect the biological characteristics of PDLSCs. Epigenetics has no changes in DNA sequence. It refers to changes in gene expression levels and functions. Environmental factors are one of the important influencing factors of epigenetics. Different environments exposure can cause changes in epigenetic modification, which in turn affect gene expression. Epigenetics is an important regulatory mechanism for the biological characteristics of stem cells. These changes in stem cells are stable, heritable, and reversible. In recent years, epigenetic regulation of PDLSCs has become a hot research topic. To make PDLSCs better applied to periodontal regeneration repair, this article reviews the effects of epigenetic regulation on the biological characteristics of periodontal ligament stem cells.

Key words: epigenetics, periodontal ligament stem cells, DNA methylation, histonemodification, non-coding RNA regulation

张琨, 刘亚丽. 牙周膜干细胞表观遗传学研究进展[J]. 口腔医学研究, 2021, 37(11): 976-980.

ZHANG Kun, LIU Yali. Advancement in Epigenetics of Periodontal Ligament Stem Cells[J]. Journal of Oral Science Research, 2021, 37(11): 976-980.

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