干细胞复合物防治医源性颌骨坏死的研究进展

doi:10.13701/j.cnki.kqyxyj.2024.06.003

摘要/Abstract

摘要： 药物相关性颌骨坏死(medication-related osteonecrosis of the jaw, MRONJ)及放射性颌骨坏死(osteoradionecrosis of the jaw, ORNJ)是两种常见的难治性医源性颌骨坏死。随着骨组织工程的迅猛发展,将生物材料负载干细胞所制成的干细胞复合物,用于对MRONJ及ORNJ的预防和治疗成为本领域研究的重点和热点。本文通过对干细胞复合物防治MRONJ和ORNJ的相关研究进行回顾,阐述干细胞复合物对MRONJ及ORNJ的防治效果和影响因素,分析该技术有待探究的问题,以期为进一步研究指明方向,为临床应用提供依据。

关键词: 颌骨坏死, 干细胞, 干细胞复合材料

Abstract: Medication-related osteonecrosis of the jaw (MRONJ) and osteoradionecrosis of the jaw (ORNJ) are two common and refractory iatrogenic osteonecrosis of the jaw, which pose significant clinical challenges. Given the swift progress in bone tissue engineering, the spotlight has shifted to stem cell composites comprised of biomaterials loaded with stem cells and their application in the prevention and treatment of MRONJ and ORNJ. This article reviews the pertinent researches on the prevention and treatment of MRONJ and ORNJ using stem cell composites. It elucidates the effects and influencing factors of stem cell composites in the context of preventing and treating MRONJ and ORNJ. Additionally, the article conducts an analysis of the unresolved issues within this technology, aiming to identify directions for future research endeavors and offering insights for clinical applications.

Key words: osteonecrosis of the jaw, stem cell, stem cell composite

史珂莹, 郑园娜. 干细胞复合物防治医源性颌骨坏死的研究进展[J]. 口腔医学研究, 2024, 40(6): 484-488.

SHI Keying, ZHENG Yuanna. Advancements of Stem Cell Composites in Prevention and Treatment of Iatrogenic Osteonecrosis of the Jaw[J]. Journal of Oral Science Research, 2024, 40(6): 484-488.

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