内质网应激与自噬在口腔疾病研究中的应用

doi:10.13701/j.cnki.kqyxyj.2018.05.001

口腔医学研究 ›› 2018, Vol. 34 ›› Issue (5): 461-466.DOI: 10.13701/j.cnki.kqyxyj.2018.05.001

• 专家特约述评 • 下一篇

内质网应激与自噬在口腔疾病研究中的应用

刘建国^1,2, 敬珮²

1. 遵义医学院口腔医学院贵州遵义 563099;
2. 贵州省普通高等学校口腔疾病研究特色重点实验室暨遵义市口腔疾病研究重点实验室贵州遵义 563006

收稿日期:2018-04-20 出版日期:2018-05-28 发布日期:2018-05-29
作者简介:刘建国二级教授,医学博士,研究生导师,历任遵义医学院口腔医学院(附属口腔医院)院长、学校科研处处长、党政办主任,现任遵义医学院党委副书记。兼任中华口腔医学会牙体牙髓病学专业委员会常委,教育部高等学校口腔医学专业教学指导委员会委员,贵州省口腔医学会名誉会长。是国务院特殊津贴专家,省管专家等22个荣誉称号获得者。主要从事牙体牙髓病学研究,主持和参与22项国家级、省部级重点课题,发表论文180篇,出版专著4部,发明专利5件。获省级科技进步奖一、二、三等奖各1项,青年科技奖1项,市厅级奖9项,兼任10余家专业期刊副主编或编委。

Endoplasmic Reticulum Stress and Autophagy in the Study of Oral Diseases.

LIU Jian-guo^1,2, JING Pei²

1. School of Stomatology, Zunyi Medical University, Zunyi 563099, China;
2. The Special Key Laboratory of Oral Diseases Research, Institution of Higher Education in Guizhou Province, the Key Laboratory of Oral Diseases Research of Zunyi City, Zunyi 563006, China

Received:2018-04-20 Online:2018-05-28 Published:2018-05-29

摘要/Abstract

摘要： 内质网是细胞内蛋白合成加工的主要场所及钙的存储库,参与了各项生理活动,当细胞受到外界刺激如缺氧、毒性物质等时,内质网则会发生应激反应,导致蛋白加工或钙调节的紊乱,损害细胞,扰乱生理功能,这也是许多疾病发生的原因之一。自噬则是一种细胞保护机制,能够清除细胞内损伤的细胞器及未折叠和错误折叠大分子蛋白,缓解内质网应激,提供新的物质及能量,帮助细胞恢复稳态提高细胞存活率。内质网应激和自噬与疾病的发生均有密切的关系,本文就内质网应激与自噬在口腔疾病研究中的作用做一述评。

关键词: 内质网应激, 自噬, 口腔疾病

Abstract: Endoplasmic reticulum (ER) is a multifauncional oranelle responsible for intracellular protein synthesis and calcium storage, involved in various physiological activities. Mutiple external stimuli such as hypoxia stress, toxic substances and so on will lead to the endoplasmic reticulum dysfunction, resulting in unfolded and/or misfolded proteins, calcium homeostasis imbalance, cells damage and physiological function disorder, which will trigger many relative diseases. Autophagy is a cytoprotective mechanism, removing intracellular damaged organelles and unfolded/misfolded proteins, which can relief endoplasmic reticulum stress, restore cell homeostasis and maintain or improve cell viability by providing new marerials and energy. Recent sudies have shown that the interaction between endoplasmic reticulum stress and autophagy may plays a critical role in the development of multiple diseases. This review summarizes the roles of endoplasmic reticulum stress and autophagy in oral diseases.

Key words: Endoplasmic reticulum stress, Autophagy, Oral diseases

刘建国, 敬珮. 内质网应激与自噬在口腔疾病研究中的应用[J]. 口腔医学研究, 2018, 34(5): 461-466.

LIU Jian-guo, JING Pei. Endoplasmic Reticulum Stress and Autophagy in the Study of Oral Diseases.[J]. Journal of Oral Science Research, 2018, 34(5): 461-466.

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内质网应激与自噬在口腔疾病研究中的应用

Endoplasmic Reticulum Stress and Autophagy in the Study of Oral Diseases.

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