微弧氧化羟基磷灰石涂层增强金属钛种植体骨整合的体内研究

doi:10.13701/j.cnki.kqyxyj.2019.11.015

口腔医学研究 ›› 2019, Vol. 35 ›› Issue (11): 1070-1073.DOI: 10.13701/j.cnki.kqyxyj.2019.11.015

微弧氧化羟基磷灰石涂层增强金属钛种植体骨整合的体内研究

王艳玲¹, 丁虹¹, 何巍^2*, 朱兰省¹, 刘爱群¹, 许小婷¹

1. 河南省中医院(河南中医药大学第二附属医院)口腔科河南郑州 450002;
2. 郑州大学第一附属医院口腔科河南郑州 450002

收稿日期:2019-08-19 出版日期:2019-11-28 发布日期:2019-11-21
通讯作者: 何巍,E-mail:heweizdyfy@163.com
作者简介:王艳玲(1979~ )女,河南人,硕士,主治医师,主要从事口腔外科及种植专业。
基金资助:
河南省科技厅科技发展计划项目(编号:142300410086)

Experimental Study on Osseointegration of Micro-arc Oxidized Hydroxyapatite Coated Titanium Implants

WANG Yanling¹, DING Hong¹, HE Wei^2*, ZHU Lansheng¹, LIU Aiqun¹, XU Xiaoting¹

1. Department of Stomatology, Henan Provence Hospital of TCM (Second Affiliated Hospital of Henan University of Traditional Chinese Medicine), Zhengzhou 450002, China;
2.Department of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, China

Received:2019-08-19 Online:2019-11-28 Published:2019-11-21

摘要/Abstract

摘要： 目的: 探索微弧氧化羟基磷灰石(HA)涂层金属钛种植体提高体内的骨整合的作用。方法: 分别使用电化学法(ELC)和微弧氧化法(MAO)制备两种HA涂层金属钛种植体,扫描电镜观察两组种植体表面形态;比格犬下颌后牙拔出后2月后进行种植体植入治疗,植入后2个月进行骨组织切片染色观察种植体与相邻骨组织的结合程度;使用X线观察两组种植体周围的骨量;使用扭力试验检测扭出种植体所需的扭力,从而判断两组种植体骨结合的强度。结果: 扫描电镜显示相比于ELC组,MAO组种植体表面更加粗糙;组织切片显示MAO组种植体与周围骨质结合更紧密;X线结果显示MAO组种植体周围骨质丰富,而ELC组周围骨质较少;扭力试验证明相比于ELC组,MAO组种植体扭出所需扭力更大,两组差异具有统计学意义(P=0.0006) 。结论: 微弧氧化羟基磷灰石涂层金属钛种植体可以作为一种性能优良的材料应用于临床种植体治疗中。

关键词: 种植体, 微弧氧化, 骨结合, 金属钛

Abstract: Objective: To explore the osseointegration of micro-arc oxidized hydroxyapatite (HA) titanium implants in vivo. Methods: Two HA coated titanium implants were prepared by electrochemistry (ELC) and micro-arc oxidation (MAO) method. The implant surface morphology was observed by scanning electron microscope. The beagle dog was treated with implants 2 months after the extraction of the posterior mandibular teeth. Bone tissue sections were stained 2 months after implantation to observe the degree of osseointegration. X-ray was used to observe the amount of bone around the implants in both groups. The torsion test was used to detect the torsion required to twist out the implants, so as to judge the degree of osseointegration of implants in two groups. Results: Scanning electron microscope showed that the surface of implants in MAO group was rougher than that in ELC group. Tissue sections showed that the implants in MAO group were more tightly bound to the surrounding bone. X-ray results showed that the MAO group had abundant bone mass around the implants, while the ELC group had less bone mass around the implants. The torsion test showed that compared with the ELC group, the MAO group required more torsion force to twist out the implant, and the differences between the two groups was statistically significant (P=0.0006). Conclusion: Micro-arc oxidized hydroxyapatite coated titanium implants can be used in clinical implant therapy as a novel material with good properties

Key words: implants, micro-arc oxidation, osseointegration, titanium

王艳玲, 丁虹, 何巍, 朱兰省, 刘爱群, 许小婷. 微弧氧化羟基磷灰石涂层增强金属钛种植体骨整合的体内研究[J]. 口腔医学研究, 2019, 35(11): 1070-1073.

WANG Yanling, DING Hong, HE Wei, ZHU Lansheng, LIU Aiqun, XU Xiaoting. Experimental Study on Osseointegration of Micro-arc Oxidized Hydroxyapatite Coated Titanium Implants[J]. Journal of Oral Science Research, 2019, 35(11): 1070-1073.

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微弧氧化羟基磷灰石涂层增强金属钛种植体骨整合的体内研究

Experimental Study on Osseointegration of Micro-arc Oxidized Hydroxyapatite Coated Titanium Implants

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