丁酸对牙周炎的影响机制研究进展

doi:10.13701/j.cnki.kqyxyj.2020.04.003

口腔医学研究 ›› 2020, Vol. 36 ›› Issue (4): 318-320.DOI: 10.13701/j.cnki.kqyxyj.2020.04.003

丁酸对牙周炎的影响机制研究进展

臧文丽, 刘俊超^*, 潘亚萍^*

中国医科大学附属口腔医院牙周病科辽宁沈阳 110002

收稿日期:2019-06-06 出版日期:2020-05-28 发布日期:2020-05-28
通讯作者: 潘亚萍,E-mail: yppan@cmu.edu.cn; 刘俊超,E-mail: liujunchao1986@126.com
作者简介:臧文丽(1995~ ),女,辽宁沈阳人,硕士在读,研究方向:牙周病致病机制。
基金资助:
国家自然科学基金(编号:81870771、81901005)

Study on Effects of Butyric Acids on Periodontitis

ZANG Wenli, LIU Junchao^*, PAN Yaping^*

Department of Periodontology, School of Stomatology, China Medical University, Shenyang 110000, China

Received:2019-06-06 Online:2020-05-28 Published:2020-05-28

摘要/Abstract

摘要： 牙周炎是由牙菌斑微生物引起的牙周支持组织慢性感染性疾病。牙菌斑生物膜是引发牙周炎的始动因子。近年来牙周致病菌通过代谢氨基酸、己糖或戊糖无氧酵解产生的代谢产物——丁酸,引起了学者们的广泛关注。研究发现,牙周炎患者龈沟液中丁酸浓度显著高于健康组,牙周炎患者口腔中高浓度丁酸可能破坏牙周上皮组织的结构和功能,在牙周炎发生发展过程中起重要作用。本文就丁酸对牙周炎的影响机制作一综述。

关键词: 丁酸, 牙周炎, 细胞周期, 细胞死亡, 炎症

Abstract: Periodontitis is a chronic infectious disease of periodontal support tissue caused by plaque microorganisms. Plaque biofilm is the initiator of periodontitis. In recent years, periodontal pathogens metabolizing amino acids, hexose or anaerobic glycolysis, a metabolite produced by pentose, butyric acid, have attracted widespread attention. The development of butyric acid in periodontitis plays an important role. The butyric acid in the gingival crevicular fluid of patients with periodontitis was significantly higher than that of the healthy group. The high concentration of butyric acid in the oral cavity of periodontal patients may destroy the structure and function of periodontal tissue. This article reviews the effects of butyric acid on periodontitis.

Key words: butyric acid, periodontitis, cell cycle, cell death, inflammation

臧文丽, 刘俊超, 潘亚萍. 丁酸对牙周炎的影响机制研究进展[J]. 口腔医学研究, 2020, 36(4): 318-320.

ZANG Wenli, LIU Junchao, PAN Yaping. Study on Effects of Butyric Acids on Periodontitis[J]. Journal of Oral Science Research, 2020, 36(4): 318-320.

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丁酸对牙周炎的影响机制研究进展

Study on Effects of Butyric Acids on Periodontitis

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