代谢组学在口腔鳞状细胞癌早期诊断及精准诊疗中的研究进展

doi:10.13701/j.cnki.kqyxyj.2022.03.001

口腔医学研究 ›› 2022, Vol. 38 ›› Issue (3): 207-211.DOI: 10.13701/j.cnki.kqyxyj.2022.03.001

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代谢组学在口腔鳞状细胞癌早期诊断及精准诊疗中的研究进展

胡勤刚^*, 泥艳红^*, 王雨晗

南京大学医学院附属口腔医院口腔颌面外科江苏南京 210008

收稿日期:2022-02-10 出版日期:2022-03-28 发布日期:2022-03-25
通讯作者: * 胡勤刚,E-mail:qghu@nju.edu.cn,泥艳红,E-mail:yanhong.ni@nju.edu.cn
作者简介:胡勤刚,主任医师,教授,博士生导师,国家临床重点专科口腔颌面外科学科带头人,专业技术二级岗,享受国务院特殊津贴。中华口腔医学会常务理事,江苏省医学会常务理事,江苏省整形美容协会会长,江苏省口腔科、整形美容医疗质量控制中心主任,江苏省医院协会口腔医院分会主任委员。全国卫生计生系统先进工作者,卫生部及江苏省有突出贡献中青年专家,国际牙医师学院院士,第八届南京市“十大科技之星”。担任《口腔医学研究》副主编,《中华口腔医学杂志》、《华西口腔医学杂志》、《实用口腔医学杂志》、《上海口腔医学杂志》、《口腔颌面外科杂志》、《中国口腔颌面外科杂志》编委。长期从事口腔颌面外科的医疗、教学和科研工作,擅长口腔颌面-头颈部良恶性肿瘤、颌面部畸形缺损等疑难复杂疾病诊疗,致力于口腔癌诊疗及其术后缺损畸形的整复等临床和基础研究。
基金资助:
国家自然科学基金面上项目(编号:82173159)江苏省重点研发项目(编号: BE2020628)

Application of Metabolomics in the Early Diagnosis and Precise Treatment of Oral Squamous Cell Carcinoma

HU Qingang^*, NI Yanhong^*, WANG Yuhan

Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, China

Received:2022-02-10 Online:2022-03-28 Published:2022-03-25

摘要/Abstract

摘要： 口腔鳞状细胞癌(oral squamous cell carcinoma, OSCC)是头颈部最为常见的恶性肿瘤之一,目前,其5年生存率仅约60%,缺乏高效、特异及快速的诊断方法是影响其预后的重要原因之一,特别是至今尚无相关肿瘤标志物或差异物。研究显示,与其他恶性肿瘤相似,OSCC发生了明显的代谢重编程,而采用代谢组学方法筛选变化的代谢酶及代谢物则可能有助于OSCC的早期筛查和精准诊疗。本文回顾了近年来OSCC相关代谢组学的研究进展,希望为改进OSCC早期诊断、精准治疗,提高患者生存率呈现新思路或新方法。

关键词: 口腔鳞状细胞癌, 代谢组学, 早期筛查, 精准诊疗

Abstract: Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors of the head and neck. Currently the 5-year survival rate of the patients is only about 60%. Difficulties for early diagnosis and precise treatment are important factors for its poor prognosis. One of the reasons is the lack of relevant tumor biomarkers for early screening and precise diagnosis. Researches have shown that, similar to other malignant tumors, OSCC also undergone significant metabolic reprogramming. Therefore, for altered obtaining changed metabolic enzymes and metabolites by metabolomics may be helpful for early screening and precise diagnosis of OSCC. This review shows the findings of metabolomics related to OSCC in recent years and hope to present new ideas or methods for improving the early diagnosis and precise therapy of OSCC patients,and advancing their survival rate.

Key words: oral squamous cell carcinoma, metabolites, early screening, precise diagnosis and treatment

胡勤刚, 泥艳红, 王雨晗. 代谢组学在口腔鳞状细胞癌早期诊断及精准诊疗中的研究进展[J]. 口腔医学研究, 2022, 38(3): 207-211.

HU Qingang, NI Yanhong, WANG Yuhan. Application of Metabolomics in the Early Diagnosis and Precise Treatment of Oral Squamous Cell Carcinoma[J]. Journal of Oral Science Research, 2022, 38(3): 207-211.

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代谢组学在口腔鳞状细胞癌早期诊断及精准诊疗中的研究进展

Application of Metabolomics in the Early Diagnosis and Precise Treatment of Oral Squamous Cell Carcinoma

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