Abstract: Through loading specific transcription factors into virus vectors and importing them into mature body cells, somatic cells can be reprogrammed to induced pluripotent stem cells (iPS cells). IPS cells can proliferate and maintain the undifferentiated state, and can differentiate into a variety of mature cells, tissues and organs. By the method of tissue engineering, when culturing iPS stem cells in the medium added with functional cell factors, and combining with the cytoskeleton, the periodontal tissue defects can be reconstructed through cells’ proliferation, differentiation, mineralization precipitation, osteoinduction and vascularization. This article systematically reviews the source, culture methods, tissue engineering-related cytokines, cell bracket, and application of iPS cells in the periodontal tissue regeneration.

Key words: Periodontal tissue regeneration, Tissue engineering iPS stem cells, Cytokines, Cells scaffold