Research Progress on the Link Mechanism between Periodontitis and Coronary Heart Disease.

doi:10.13701/j.cnki.kqyxyj.2017.04.027

Abstract

Abstract: Periodontitis has become the most leading cause of tooth loss in adults. The survey shows that about 44%-57% and 10% of adults have moderate and severe periodontitis all over the world. Coronary heart disease (CHD) is one of the diseases with higher mortality rate, which has serious harm to human health. The main pathological basis of CHD is atherosclerosis (AS) and the thrombus which are formed due to the plaque rupture. There are some connections between periodontitis and CHD. Periodontal pathogens colonized in coronary artery and produced lots of cytokines and adhesion molecules which can cause systemic inflammation, abnormal lipid and coagulation status. They further activated innate immune system and then biological inflammation, chemical inflammation, immune inflammation formed. Ultimately, AS was formed and aggravated, followed by CHD. This paper aims to summarize newly research progress on the link mechanism between periodontitis and CHD.

Key words: Periodontitis , Coronary heart disease , Atherosclerosis Inflammatory cytokines

CLC Number:

R781.4

LI Shuang, YI Gen-yun, LI Zhi-qiang, ZHOU Jian-ye.. Research Progress on the Link Mechanism between Periodontitis and Coronary Heart Disease.[J]. Journal of Oral Science Research, 2017, 33(4): 455-458.

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