Abstract: Objective: To compare the curative effect of polyantibiotic paste and Vitapex for primary teeth of pulp infection and periradicular lesions by systematical review. Methods: The data up to June 30, 2016 were collected by searching in Cochrane Library, EMbase, PubMed, CBM, CNKI and VIP. Two reviewers independently screened the literatures according to the inclusion and exclusion criteria and extracted data from the literatures. The methodological quality of selected studies was assessed. The RevMan 5.0 software was used for Meta-analysis and the Stata 12.0 was for evaluating the publication bias. Results: A total of 16 studies were selected and 3852 teeth were involved. The results of Meta-analysis showed that the total successful rate between two groups [RR=1.02, 95%CI (1.00-1.04), Z=1.85, P=0.06] and the successful rate of 12 months [RR=1.01, 95%CI (0.98-1.03), Z=0.60, P=0.55] were not significantly different; the successful rate of 6 months [RR=1.02, 95%CI (1.00-1.04), Z=2.15, P=0.03] and the successful rate of over 24 months [RR=1.75, 95%CI (1.11-2.76), Z=2.42, P=0.02] were significantly different. Conclusion: Compared with the curative effect of Vitapex for primary teeth of pulp infection and periradicular lesions, the successful rate of polyantibiotic paste was superior, especially for the cases observed over two years.

Key words: Polyantibiotic paste , Vitapex , Primary teeth , Pulp infection , Periradicular lesions , Systematic review, Meta-analysis