Meta-Analysis of Association Between Interleukin-1β T-31C Polymorphism and Chronic Periodontitis Susceptibility.

doi:10.13701/j.cnki.kqyxyj.2017.04.010

Abstract

Abstract: Objective: To investigate the association between interleukin-1β (IL-1β) T-31C polymorphism and periodontitis risk using a meta-analysis. Methods: A comprehensive literature search from PubMed, Embase and Chinese National Knowledge Infrastructure up to May 26, 2016 was made. Two authors selected the studies and extracted data, and then the meta-analysis was conducted using the Comprehensive Meta-Analysis v2 software. Results: Finally eight case-control studies were yielded. All five genetic models revealed non-significant association between the IL-1β T-31C polymorphism and periodontitis risk. Sensitivity analysis indicated that the results were robust and the subgroup analysis yielded similar results. Conclusion: Based on current evidence, the IL-1β T-31C polymorphism was not associated with PD susceptibility in overall population.

Key words: Interleukin-1, Periodontitis , Polymorphism , Meta-analysis

CLC Number:

R781.4

JIA Cheng, LI Xiao-yan, SUN Feng, XIA Ling-yun, ZENG Xian-tao.. Meta-Analysis of Association Between Interleukin-1β T-31C Polymorphism and Chronic Periodontitis Susceptibility.[J]. Journal of Oral Science Research, 2017, 33(4): 386-389.

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