Study on ENPP1 Gene SNP Rs6925433 Polymorphism among Uyghur Nationality in Kashgar.

doi:10.13701/j.cnki.kqyxyj.2017.06.014

Abstract

Abstract: Objective: To explore the gene polymorphisms distribution of ectonucleotide phosphodiesterase 1 (ENPP1) SNP rs6925433 among Uyghur nationality in Kashgar, Xinjiang. Methods: Two hundred and thirteen oral epithelial sample cells were collected from Uyghur nationality people, gene sequencing by dideoxy-mediated chain termination method after whole-genome DNA extraction, the distribution of gene polymorphisms of this study was analyzed by DNA star and Chromas 2 software, then compared with other nationalities which had been reported. Results: Among the Uyghur nationality in Kashgar, the frequencies of rs6925433 GG, AG, and AA gene types were 28.17%,50.23%, and 21.60%, and the allele frequency of A/G were 46.71% and 53.29%. Compared with other nationalities, it was found that the frequency of GG was higher and AA was lower than Beijing Han nationality (P=0.046), and AA was higher and GG was lower than Northern and Western European (P=0.010). Conclusion: The gene polymorphisms distribution of ectonucleotide phosphodiesterase (ENPP1) SNP rs6925433 among Uyghur nationality in Kashgar was obviously different from other nationalities.

Key words: Ectonucleotide phosphodiesterase (ENPP1), Single nucleonic polymorphisms , Uyghur nationality

CLC Number:

R783.2

GE Shu-peng, HAN Xiang-zhen, ZHOU Qi-qi, SONG Yan-yan, HE Hui-yu. Study on ENPP1 Gene SNP Rs6925433 Polymorphism among Uyghur Nationality in Kashgar.[J]. Journal of Oral Science Research, 2017, 33(6): 633-636.

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