Abstract: Objective : To investigate the clinical efficacy of autologous dentin matrix granule in the immediate implantation in patients with severe periodontitis. Methods: One mandibular molar caused by periodontitis was pulled out and prepared into dentin matrix (DM). Dental implantation was performed immediately after the surgery. Autologous DM was used for guided bone regeneration. The stability of implant was detected. The panoramic radiograph and restoration were performed six months after surgery. Results: The ISQ value of implant was 52.7. The X-ray and clinical examination showed the bone integration half a year after surgery, and the function of implant was good at one-year follow-up. Conclusion: DM granule can be applied for the filling of bone defect in implantation, even in periodontitis case. But its long-term effect remains to be further observed.

Key words: Dentin matrix, Periodontitis, Immediate implantion, Guided bone regeneration