Therapeutic Effect of Small Intestinal Submucosa in Preventing Frey's Syndrome after Surgery of Parotid Benign Tumor

doi:10.13701/j.cnki.kqyxyj.2019.08.012

Abstract

Abstract: Objective: To observe and evaluate the effect of small intestinal submucosa in preventing Frey's syndrome after surgery of parotid benign tumor. Methods: A total of 63 patients with benign parotid tumors were divided to two groups according to their inclination. The observation group used small intestinal submucosa after surgery while control group did not. There were 32 cases in the observation group and 31 cases in the control group. All cases were followed up 6 to 18 months after surgery to analyze the occurrence of Frey's syndrome and foreign body feeling. The occurrence of Frey's syndrome was evaluated by subjectively and objectively ways. Results: Positive rates of subjective evaluation were 0% in the observation group and 19.35% in the control group, and the positive rates of objective evaluation in two groups were 3.13% and 48.39%, respectively. The observation group was superior to the control group (P<0.05). There was no significant difference in the foreign body sensation between two groups (P>0.05). Conclusion: Using small intestinal submucosa patch in parotid benign tumor can effectively prevent the occurrence of Frey's syndrome after surgery, which is simple, comfortable and worthy of spread.

Key words: small intestinal submucosa, parotid gland, benign tumor, Frey syndrome

LIU Kun, YAN Guangpeng, CHEN Junwen, GAO Peng, LI Jun. Therapeutic Effect of Small Intestinal Submucosa in Preventing Frey's Syndrome after Surgery of Parotid Benign Tumor[J]. Journal of Oral Science Research, 2019, 35(8): 772-775.

References

[1] Motz KM, Kim YJ. Auriculotemporal syndrome (Frey syndrome) [J]. Otolaryngol Clin North Am, 2016, 49(2):501-509.
[2] 孙德平.腮腺良性肿瘤改良术式的疗效及并发症探讨[J].华西医学,2017,32(4):541-544.
[3] de Bree R, van der Waal I, Leemans CR.Management of Frey syndrome [J]. Head Neck, 2007, 29(8):773-778.
[4] Guntinas LO, Gabriel B, Klussmann JP. Risk of facial palsy and severe Frey syndrome after conservative parotidectomy for begin disease:analysis operations [J]. Acta Otolaryngol, 2006, 126(10):1104-1109.
[5] Rustemeyer J, Eufinger H, Bremerich A. The incidence of Frey's syndrome [J]. J Craniom Axillofac Surg, 2008, 36(1):34-37.
[6] 王勖成,龚忠诚,林兆全,等.腮腺区良性肿瘤术后并发症发生的相关因素分析[J].中国口腔颌面外科杂志,2017,15(3):259-263.
[7] Ugur D, Oguz B, Behzat N, et al. The efficiacy of sternocleidomastoid muscle flap on Frey's syndrome via a novel test: galvanic skin response [J]. Indian J Otolaryngol Head Neck Surg, 2014, 66 (Suppl 1):291-298.
[8] 李金超,刘茁,高子龙,等.Frey综合征临床预防的研究进展[J].临床口腔医学杂志,2015,31(7):445-447.
[9] de Ru JA, van Benthem PP, Bleys RL, et al. Prevention of Frey syndrome in parotid gland surgery [J]. J Otolaryngol, 2007, 36(5):291-295.
[10] Sinha UK, Saadat D, Doherty CM, et al. Use of AlloDerm implant to prevent frey syndrome after parotidectomy [J]. Arch Facial Plast Surg, 2003, 5(1):109-113.
[11] 周静,张进锋,邓蔡.国内异种脱细胞真皮基质预防腮腺术后Frey's综合征的Meta分析[J].口腔医学,2014,34(4):261-265.
[12] Kim BS, Mooney DJ. Development of biocompatible synthetic extracellular matrices for tissue engineering [J]. Trends Biotechnol, 1998, 16(5):224-230.
[13] Kropp BP, Cheng EY. Bioengineering organs using small intestinal submucosa scaffolds: in vivo tissue engineering technology [J]. J Endourol, 2000, 14(1):59-62.
[14] Badylak S, Liang A, Record R, et al. Endothelial cell adherence to small intestinal submucosa: an acellular bioscaffold [J]. Biomaterials, 1999, 20(23-24):2257-2263.
[15] Ueno T, Pickett LC, de la Fuente SG, et al.Clinical application of porcine small intestinal submucosa in the management of infected or potentially contaminated abdominal defects [J]. J Gastrointest Surg, 2004, 8(1):109-112.
[16] Lantz GC, Badylak SF, Hiles MC, et al. Small intestinal submucosa as a vascular graft: a review [J]. J Invest Surg, 1993, 6(3):297-310.
[17] 杨凯,张育敏,张乃丽,等.小肠黏膜下层在组织修复重建中的应用研究进展[J].中国修复重建外科杂志,2013,27(9):1138-1143.