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Journal of Oral Science Research

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    28 August 2019, Volume 35 Issue 8 Previous Issue    Next Issue
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    Development of Digital Technology in Implant Dentistry-A Systematic Review
    LIU Zhonghao, SHEN Xiaojing, ZHOU Wenjuan
    2019, 35(8): 725-729.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.001
    Abstract ( 786 )   PDF (977KB) ( 494 )  
    Implant dentistry, along with social media and dentistry, is undergoing a digital revolution, which affects the whole process of implant treatment protocol, including data collection for patient information, surgical planning, implant placement, and the later restoration. The aim of this paper is to review the application of cone-beam computed-tomography (CBCT), intraoral scanning, facial scanning, digital workflow for implant treatment, and computer-aided design and computer-aided manufacturing (CAD/CAM). With the knowledge of artificial intelligence, this paper also takes a perspective insight into digital implantology.
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    Research Progress of Lactoferrin in Stomatology Medical Domain
    ZHOU Tian, KANG Na
    2019, 35(8): 730-733.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.002
    Abstract ( 332 )   PDF (808KB) ( 307 )  
    Lactoferrin is a non-heme and iron-binding glycoprotein with various physiological functions, which plays an important role in anti-inflammatory, anti-bacterial, anti-viral, anti-tumor, and immune regulation. Lactoferrin can promote bone growth, effectively stimulate the proliferation and differentiation of osteoblasts and inhibit the formation of osteoclasts under physiological concentrations. In this article, the research progress of lactoferrin in stomatology medical domain is reviewed in order to give a comprehensive understanding of lactoferrin.
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    Research Progress of Simvastatin in Promoting Osseointegration and Improving Poor Osteogenic Conditions
    XIN Xirui, ZHOU Yanmin
    2019, 35(8): 734-737.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.003
    Abstract ( 274 )   PDF (795KB) ( 326 )  
    With the rapid development of medical technology and the continuous improvement of people's living condition, implant restoration is more likely to become the first choice for patients with dentition defects. For a along time, poor bone condition and poor osseointegration are important causes of implant failure. How to promote the integration of implants with surrounding bone tissue and further improve the initial stability of implants in patients with poor bone condition has become a hot issue for many scholars. A large number of studies have confirmed that simvastatin has the effect of promoting osteogenesis. Simvastatin has great potential for osteogenesis under adverse conditions, such as osteoporosis, periodontitis, and diabetes. This article reviews the mechanism of simvastatin in promoting osseointegration of implants, the mode and dosage of administration, and the improvement of poor osteogenesis conditions.
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    Research Progress on Effects of Titanium Surface Roughness on Fibroblast Growth
    JIANG Yao, LI Hong
    2019, 35(8): 738-740.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.004
    Abstract ( 263 )   PDF (771KB) ( 257 )  
    Successful integration of dental implant with gingival connective tissue plays an extremely crucial role on the longtime survival of the implant. Good soft tissue sealing is related to the roughness of pure titanium surface. The adhesion and proliferation of fibroblasts on the implant surface in soft tissue is the key to establish and maintain a good mucosal sealing. In recent years, researchers have performed many in vitro and in vivo experiments to study the relationship between surface roughness of pure titanium and fibroblasts. In this paper, the research progress of the influence of surface roughness of pure titanium implants on the growth of fibroblasts is reviewed, with aim to provide a theoretical basis for the future development of oral implant.
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    Research Progress on Preservation and Reconstruction of Gingival Papilla around Implants
    WANG Ning, YAN Xing
    2019, 35(8): 741-743.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.005
    Abstract ( 262 )   PDF (762KB) ( 306 )  
    With the development of dental implant technology, the requirement of implant restoration is not limited to the complete and functional restoration of dentition. Good crown shape, color, soft tissue, and other aesthetic standards have become one of the standards to evaluate the implant restoration. The loss of gingival papilla height affects the aesthetic effect and reduces the patient's satisfaction with implants. At present, techniques for preservation and reconstruction of gingival papilla height have been continuously developed to solve the problem of "black triangle" caused by retraction of gingival papilla. However, the prognosis of soft tissue management is unpredictable and needs to be confirmed by large sample's tracking. In this paper, the factors influencing the height of the gingival papilla around implants are analyzed, and the methods to preserve and reconstruct the height of the gingival papilla during the whole process from tooth extraction to final implant restoration are reviewed.
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    Naringin in Nanometer Hydroxyapatite Collagen Scaffold Enhanced the Proliferation and Osteoblastic Differentiation of Human Dental Pulp Stem Cells in Vivo
    HOU Tingting, PAN Shuan, LI Yanping, HE Lina, XIAO Wanlu, NIU Yumei
    2019, 35(8): 744-747.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.006
    Abstract ( 250 )   PDF (1615KB) ( 194 )  
    Objective: To evaluate the effects of naringin-hydroxyapatite collagen scaffold (Nar-HA/COL) on proliferation and osteoblastic differentiation of human dental pulp stem cells (hDPSCs). Methods: HDPSCs were isolated and cultured on Nar-HA/COL scaffolds. CCK-8 was used to detect the proliferation ability. The osteoblastic differentiation potentials were assessed by alkaline phosphatase assay kit, Alizarin red S histochemical staining, and western Blot. Results: The proliferation ability, ALP activity, mineralization potential, RUNX-2, and BMP-2 proteins expression of hDPSCs were enhanced by 0.5% Nar-HA/COL scaffolds. Conclusion: The results showed Nar-HA/COL scaffolds could enhance the proliferation and osteoblastic differentiation abilities of hDPSCs.
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    Influence of Pre-phosphoric Acid Etching on Bonding Strength of Two-step Self-etching Adhesives to Enamel
    LI Xiuhua, YU Peng, TIAN Fucong, WANG Xiaoyan
    2019, 35(8): 748-751.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.007
    Abstract ( 210 )   PDF (1389KB) ( 200 )  
    Objective: To investigate the effects of phosphoric acid (P) etching pretreatment on the bonding strength of two-step self-etching adhesives SE BOND (SE) and VERSA (VE) to enamel. Methods: 18 fresh and intact bovine incisors were selected and divided into 6 groups according to using pre-phosphoric acid etching and primer (solution ①) or not: SE①+SE②; P+SE①+SE②; P+SE②; VE①+VE②; P+VE①+VE②; P+VE②. The micro-tensile bond strength (MPa) was measured. The enamel samples treated with phosphoric acid, SE① solution, phosphoric acid + SE① solution, VE① solution, and phosphoric acid + VE① solution were observed with SEM. Results: The difference of the microtensile bond strengths of SE①+SE②, P+SE①+SE②, and P+SE② was not statistically significant (P>0.05). The microtensile bond strengths of the P+VE①+VE② group was significantly higher than the VE①+VE② group (P<0.05). The SEM presented a typical honeycomb structure of enamel surface after phosphoric acid treatment. However, SE① solution and VE① solution did not change the enamel surface obviously, which was covered by the smear layer. Conclusion: Phosphoric acid pretreatment improves the microtensile bond strength of VE to enamel. When phosphoric acid pretreatment was applied on enamel surface, primer (solution ①) still be recommended.
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    Effect of Fluoride-resistant Streptococcus Mutans on Adhesion of CAD/CAM Ceramics to Teeth
    GUO Xinwei, ZHAO Hongyan, CHENG Boqun, QIAN Xin, ZHANG Zhimin
    2019, 35(8): 752-756.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.008
    Abstract ( 182 )   PDF (2705KB) ( 149 )  
    Objective: To investigate the effect of Streptococcus mutans and its fluoride-resistant strains on the bonding interface between three kinds of ceramics and enamel, dentin, and fluid resin. Methods: Fluoride-resistant strains of Streptococcus mutans were induced. And ceramic-enamel/dentin/fluid resin specimens were prepared. The specimens were immersed in Streptococcus mutans UA159, its fluoride-resistant strain, and BHI culture medium, respectively. The bonding interface was observed under stereomicroscope and electron microscope for 14 days. Results: (1) Ceramic-adhesive interface: the cracks between ceramic and adhesive dipped in UA159 were more than those dipped in fluoride-resistant strains; the cracks between resin-based ceramic Lava Ultimate and adhesive were the most; (2) adhesive-teeth interface: the cracks between adhesive and fluid resin were the least; UA159 and its fluoride-resistant strains had similar influence on the interface. Conclusion: Streptococcus mutans and its fluoride-resistant strains can destroy the interface of ceramic-adhesive-dental tissue, and the most destructive effect is happened in resin-based ceramics.
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    Effect of EDTA Pretreatment on Dentin Bonding in Non-carious Sclerosis of Tooth Neck
    CAO Baiyu, LIN Yi, XU Jie
    2019, 35(8): 757-760.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.009
    Abstract ( 246 )   PDF (1315KB) ( 179 )  
    Objective: To investigate the effect of EDTA pretreatment on dentin bonding in non-carious sclerosis of tooth neck. Methods: 40 teeth with representative wedge-shaped defects extracted from periodontal disease patients were randomly divided into four groups (C1, C2, C3, and C4), 10 in each group. Three experiments were carried out as follows: (a) the teeth were treated with different concentrations of EDTA (10%, 15%, 20%) for 60 s and 35% phosphoric acid for 30 s; then coated with Easy One adhesive, filled with resin, and hot and cold treated for 5000 cycles. The fracture mode and bonding strength of the bonding interface were observed; (b) the same as (a) except the Easy One adhesive with 0.1% rhodamine B; (c) the same as (a) except that the filled teeth were immersed in the 50% alcohol solution with 0.1% Rhodamine B and then performed 5000 cycles of cold and hot cycles. Results: The higher the concentration of EDTA, the more obvious the bonding effect of cervical sclerotic dentin (CSD), the higher the quality of mixed layer and resin protrusion, the closer the bonding between resin and CSD, the stronger the penetration of resin into CSD, and the less the microleakage of bonding interface (P<0.05). Conclusion: EDTA can be used as a surface pretreatment agent for CSD and can be widely used in the clinic to reduce the failure rate of CSD resin bonding.
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    Effect of Aspirin/Platelet-rich Fibrin Complex on Bone Restoration of Peri-implant Bone Defects
    CHEN Rui, LI Fenglan
    2019, 35(8): 761-765.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.010
    Abstract ( 250 )   PDF (3958KB) ( 193 )  
    Objective: To evaluate the effect of Aspirin/platelet-rich fibrin (PRF) complex on repairing peri-implant bone defects in rats. Methods: A total of 30 male Sprague-Dawley rats (8 weeks of age) were used in the present study. 12 rats were used to prepare PRF and aspirin/PRF complex (100 mg/L) and 18 rats were used to prepare the peri-implant bone defects on both sides of tibia, and bone defects (1.5 mm×2.0 mm) were created along one distal bone wall of each implant sites. After implants placement, the rats were randomly divided into three groups: the bone defects in control group was left empty; the bone defects in PRF control group was implanted with PRF alone; and bone defects of aspirin/PRF complex group was implanted with aspirin/PRF complex. Three rats from each group were randomly sacrificed at 4 weeks and 8 weeks after implantation surgery. Specimens were subjected to general observation, bone histological observation, and histomorphometric analysis. Results: 4 weeks after implantation surgery, the implant bone contact rate in the aspirin/PRF complex group [(57.30±6.76)%] was significantly higher than that in the PRF control group [(45.93±6.53)%] and the control group [(27.35±10.31)%] (P＜0.05), and the implant bone contact rate in the PRF control group was also significantly higher than that in the control group (P＜0.05). The new bone areas percentage in the aspirin/PRF complex group [(24.34±6.11)%] was significantly higher than that in the PRF control group [(14.30±4.86)%] and the control group [(10.79±2.14)%] (P＜0.05). There was no statistical difference between PRF control group and control group (P>0.05). 8 weeks after implantation surgery, the implant bone contact rate in the aspirin/PRF complex group [(64.34±6.02)%] was significantly higher than that in the PRF control group [(52.62±6.08)%] and the control group [(54.32±6.57)%] (P＜0.05). There was no statistical difference between PRF control group and control group (P>0.05). In term of the new bone areas percentage, there was no statistical difference among aspirin/PRF complex group [(30.16±3.58)%], PRF control group [(26.27±5.36)%], and control group [(25.33±4.25)%] (P>0.05). Conclusions: Aspirin/PRF complex promotes bone regeneration in the bone defect area surrounding implant in the early stage of bone healing, shortens the implants and bone healing cycle, and improves the implants osseointegration.
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    Application of Individualized in-situ Moulding Guide Plate in Mandibular Reconstruction using a Vascularized Iliac Muscle Flap
    LU Tingwei, LIU Chaoming, WU Tianfu, SHAO Zhe, SUN Yanfang, SUN Zhijun, LIU Bin
    2019, 35(8): 766-771.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.011
    Abstract ( 193 )   PDF (4494KB) ( 238 )  
    Objective: To analyze the clinical effect of in-situ moulding of vascularized iliac bone before disconnecting vessel pedicle using individualized in-situ moulding guide plate. Methods: 20 patients with mandibular tumors who underwent tumor resection were selected and repaired with autologous iliac muscle flap. The in-situ moulding guide plate was a guide plate that using a bridge to connect two mandibular ends after osteotomy. After iliac bone extraction, the bone was grinded according to the in-situ moulding guide plate. 10 cases were defined as group A which used in-situ moulding guide plate, and 10 cases defined as group B without guide plate. The deviations between post-operative and preoperative design were compared. Results: All 20 operations were successful. Patients recovered well. The average operation time of group A and group B were 5.24h and 7.09h, respectively (P=0.01). The average hospital days after operation were 9.6d and 11.2d, respectively (P=0.02). The average deviations of condylar distance for group A with group B were (1.44±.99) mm and (1.92±0.81) mm, respectively (P=0.44), the average deviations of mandibular angle distance after operation were (1.83±0.80) mm and (2.50±1.50) mm, respectively (P=0.36), and the average deviations from the midpoint of mandible to the midpoint of condylar connection were (0.97±0.40) mm and (2.67±3.31) mm, respectively (P=0.29). Conclusion: The application of individualized in-situ moulding guide plate can improve the operation efficiency and accuracy and promote recovery.
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    Therapeutic Effect of Small Intestinal Submucosa in Preventing Frey's Syndrome after Surgery of Parotid Benign Tumor
    LIU Kun, YAN Guangpeng, CHEN Junwen, GAO Peng, LI Jun
    2019, 35(8): 772-775.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.012
    Abstract ( 200 )   PDF (1503KB) ( 155 )  
    Objective: To observe and evaluate the effect of small intestinal submucosa in preventing Frey's syndrome after surgery of parotid benign tumor. Methods: A total of 63 patients with benign parotid tumors were divided to two groups according to their inclination. The observation group used small intestinal submucosa after surgery while control group did not. There were 32 cases in the observation group and 31 cases in the control group. All cases were followed up 6 to 18 months after surgery to analyze the occurrence of Frey's syndrome and foreign body feeling. The occurrence of Frey's syndrome was evaluated by subjectively and objectively ways. Results: Positive rates of subjective evaluation were 0% in the observation group and 19.35% in the control group, and the positive rates of objective evaluation in two groups were 3.13% and 48.39%, respectively. The observation group was superior to the control group (P<0.05). There was no significant difference in the foreign body sensation between two groups (P>0.05). Conclusion: Using small intestinal submucosa patch in parotid benign tumor can effectively prevent the occurrence of Frey's syndrome after surgery, which is simple, comfortable and worthy of spread.
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    Effect of Down-regulation of Mucin-1 on Growth of Xenografts of Human Tongue Squamous Cell Carcinoma Tca-8113 in Nude Mice
    DENG Xuan, YANG Fang, TANG Xiqing
    2019, 35(8): 776-780.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.013
    Abstract ( 194 )   PDF (3156KB) ( 152 )  
    Objective: To investigate the effect of down-regulation of mucin-1 (MUC1) expression on the growth of xenografts of human tongue squamous cell carcinoma Tca-8113 in nude mice. Methods: Tca-8113 cells were infected with MUC1-short hairpin RNA (shRNA) lentivirus. Quantitative real-time PCR (qPT-PCR) and western blot were used to detect the expression of MUC1 in infected Tca-8113 cells. The squamous cell carcinoma of tongue xenografts in nude mice were constructed by subcutaneous injection of Tca-8113 cells infected with MUC1-shRNA lentivirus. The volume of tumors was observed and the growth curve was drawn. Hematoxylin-eosin (HE) and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) staining were used to observe the pathological changes and apoptosis of xenografts. The expression of MUC1, B-cell lymphoma-2 (Bcl-2), Bcl-2-associated X (Bax), Cleaved-cysteine aspartic acid specific protease-3 (Cleaved-caspase-3), and proliferating cell nuclear antigen (PCNA) in tumors were detected by western blot. Results: After infected with MUC1-shRNA lentivirus, the mRNA and protein expression of MUC1 in Tca-8113 cells decreased significantly (P<0.05). Compared with the control group and negative control group (MUC1-shCON), the volume of tumors in the MUC1-shRNA group was significantly reduced (P<0.05), the apoptosis of transplanted tumor tissue was serious, and the expressions of MUC1, Bcl-2 and PCNA were significantly decreased (P<0.05), while the expressions of Bax and cleaves-caspase-3 protein were increased (P< 0.05). Conclusion: The down-regulation of MUC1 can significantly inhibit the growth of tumor xenograft of human tongue squamous cell carcinoma Tca-8113 in nude mice.
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    Case Report and Literature Review of 15 Patients with Traumatic Bone Cyst
    LI Delong, KOU Yurong, GE Yimin, WANG Zechen, ZHAO Tengfei, NING Chunliu, HUANG Shaohui
    2019, 35(8): 781-785.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.014
    Abstract ( 225 )   PDF (1482KB) ( 205 )  
    Objective: To study the clinical symptoms, imaging features, and intraoperative situation of traumatic bone cyst. Methods: 15 cases of traumatic jaw cysts were retrospectively studied on the clinical information and treatment programs. Furthermore, the patients were followed up and evaluated about the prognosis. Results: There were no postoperative complications occurred in all patients such as infection, relapse, and lower alveolar nerve numbness. Compared with preoperative X-ray film, the range of lesion was obviously reduced and there was no relapse. Conclusion: The main feature of traumatic jaw cysts was a cavity lesion without epithelial lining and lacking contents or containing liquid. The main treatment was surgery excision, which could result in a good prognosis.
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    CBCT Evaluation on Upper Airway Volume after Rapid Maxillary Expansion in Class Ⅱ Division 1 Adolescents
    REN Liuyang, XIONG Hui
    2019, 35(8): 786-789.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.015
    Abstract ( 228 )   PDF (1848KB) ( 142 )  
    Objective: To assess upper airway changes immediately after rapid maxillary expansion (RME) in Class Ⅱ Division 1 malocclusion adolescent. Methods: Sixteen subjects with Class Ⅱ, Division 1 malocclusion and maxillary transverse deficiency underwent RME. CBCT images were collected pre-RME (T1) and post-RME (T2). Measurements were taken with Dolphin Imaging Software® 11.8. Paried t test (P＜0.05) was used to compare differences between T1 and T2. Results: The upper airway volume and nasopharynx volume increased significantly (P<0.05) but there was no significant difference in retropalatal airway volume, retroglossal airway volume, and minimal cross-sectional area. Conclusion: There was significant increase in upper airway volume and nasopharynx volume after RME in Class Ⅱ Division 1 malocclusion adolescent.
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    Application of Molar Retractor in Correction of Bilateral Impacted Mandibular Second Molars
    BEI Min, LI Huang, MA Qiaolin, YAN Xiang
    2019, 35(8): 790-793.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.016
    Abstract ( 201 )   PDF (3412KB) ( 170 )  
    Objective: To investigate the application of molar retractor in the correction of bilateral impacted mandibular second molars and observe the clinical effects. Methods: The case group consisted 5 patients with bilateral impacted mandibular molars. All mandibular third molars had been extracted before treatment. Molar retractors were manufactured and used in these patients. The clinical effects were observed and evaluated. Results: All the impacted second molars had been corrected successfully. The average period of treatment was 7 months. The mean change value of the inclination of the right mandibular impacted molars was 49.60° and that of the left mandibular impacted molars was 45.40°. Conclusion: Molar retractor effectively corrected the bilateral impacted mandibular second molars and could enable orthodontist to upright the impacted molars rapidly.
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    CBCT Study on Three Dimensional Alveolar Bone Changes and Root Absorption of Maxillary Incisors in Patients with Class Ⅱ Division 1 Malocclusion
    CHEN Liangjiao, WANG Zhaojian, HE jingyi, DENG Yulian, FENG Zijun
    2019, 35(8): 794-797.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.017
    Abstract ( 217 )   PDF (1735KB) ( 145 )  
    Objective: To compare the three dimensional bone changes of maxillary incisors in patients with class Ⅱ division 1 malocclusion before and after orthodontic treatment, and to observe the root absorption and dehiscence/fenestration. Methods: Standard samples were collected. The height and thickness of alveolar bone were measured. The change of root length was observed. Results: The height of alveolar bone in mesial and distal side was greater than that of buccal and lingual side. The dehiscence was less than 2mm on the buccal/lingual side and no fenestration was seen. After orthodontic treatment, the three dimensional alveolar bone changes were observed. The height and thickness of the alveolar bone in lingual side were reduced. The dehiscence in lingual side was increased. The orthodontic treatment caused a certain degree of root absorption. Conclusion: Orthodontic treatment caused the decrease of height and thickness of alveolar bone. The dehiscence in lingual side was increased. The orthodontic treatment caused a certain degree of root absorption. However, it basically does not affect the periodontal health of anterior teeth.
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    Effect of Three Resin Adhesives on Color Stability of IPS E.Max Press Cast Porcelain and Zirconia All-ceramic Restorations
    YUAN Shuo, CHEN Zhiyu, MA Xiaoping
    2019, 35(8): 798-801.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.018
    Abstract ( 214 )   PDF (767KB) ( 170 )  
    Objective: To investigate the effect of three resin adhesives on the color stability of IPS E.Max press cast porcelain and zirconia all-ceramic restorations. Methods: A total of 45 zirconia all-ceramic specimens and 45 cast-ceramic specimens were prepared and randomly divided into A-F groups, with 15 specimens in each group. Zirconia all-ceramic specimens in groups A, B, and C were bonded with FujiCEM, RelyX Unicem, and RelyX Veneer resins, respectively. Cast-ceramic specimens in group D, E, and F were bonded with FujiCEM, RelyX Unicem, and RelyX Veneer resins, respectively. Shadepilot digital colorimeter was used to measure the optical value (L, a, b) before (T0), 1 month (T1), 3 months (T2), 6 months (T3), and 9 months (T4) after immersion, respectively. The color difference (△E) was calculated. Results: At T0-T4 time points, there were significant differences in L*, a*, b*, and △E values between group A, B, C and D, E, F (P<0.05). At T1-T4 time points, the value of △E in group A was higher than that in group B and C (P<0.05), and the value of △E in group D was higher than that in group E and F (P<0.05). During the nine-month experiment, no discernible color changes were observed in group A, B, C, E and F. In group D, discernible color changes were observed at T3 (6 months) time point and further increased at T4 (9 months) time point. Conclusion: Compared with Relyx Unicem and Relyx, Fujicem has the greatest influence on color stability, especially on the color stability of cast-ceramic.
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    Veracity of Digital Models and Stone Cast by Studying Distance and Angle
    YANG Leining, HAN Xiaopeng, ZHANG Mengmeng, SUN Dong, LIU Zhonghao
    2019, 35(8): 802-805.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.019
    Abstract ( 199 )   PDF (1071KB) ( 166 )  
    Objective: To test the veracity of digital models and stone cast by studying the distance and angle. Methods: A dental study model was used to pour 10 sets of stone casts and scan 20 sets of digital models by 3-shape trios and 3-shape D700,respectively. The veracity of these models were tested by paired t-test through studying the distance and angle. Results: There was no difference between these models. The digital models of trios were the most different from the study model, followed by D700 and stone cast. Meanwhile, the difference between the digital models of trios and stone cast was larger than others. Conclusion: All these models showed good veracity. Furthermore,the models of D700 and the stone cast were slightly better that of Trios.
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    Effect of Oral Lichen Planus-associated Myofibroblasts on Migration and Tube-formation of Vascular Endothelial Cells
    MENG Wenxia, FENG Lu, LIU Shuguang, ZHOU Huixi, LI Zhiqiang
    2019, 35(8): 806-809.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.020
    Abstract ( 248 )   PDF (2877KB) ( 193 )  
    Objective: To observe the effect of oral lichen planus (OLP)-associated myofibroblasts (MFs) on the migration and tube-formation of vascular endothelial cells, and to elucidate the role of OLP-MFs in the angiogenesis of oral lichen lesions. Methods: Tissues were obtained from the OLP patients. The specimens were analyzed using the primary separation culture methods. Cultures at passage three were used for the cellular identification of OLP-MFs. Normal fibroblasts and untreated HUVEC were set as the control group. Transwell cell migration assay was used to detect the migration of OLP-MFs after co-cultured with HUVEC. Endothelial tube formation assay was used to detect the tube formation of OLP-MFs. Results: Compared with the control groups, OLP-MFs cells highly expressed α-SMA and had the related characteristics of myofibroblasts. Considered the migration cell number was 100% in HUVEC group, NFs + HUVEC group was (114.86±8.02)%, OLP-MFs + HUVEC group was (169.83±7.58)%, and OLP-MFs significantly promoted the migration of HUVEC. The tube length of OLP-MFs + HUVEC was (159.90±12.98)%, and the control groups were (100.38±10.54)% and 100%, respectively. Conclusion: The activated fibroblasts exist in the microenvironment of oral lichen planus, and can significantly promote HUVEC migration and tube length formation.
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    Analysis of Risk Factors of Chemotherapy-induced Oral Mucositis
    LI Qingfu, LI Xiqing, JIANG Li, MA Xin
    2019, 35(8): 810-813.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.021
    Abstract ( 206 )   PDF (764KB) ( 173 )  
    Objective: To explore the risk factors of oral mucositis induced by chemotherapy. Methods: Through retrospective analyzing the clinical data of 205 cases of malignant tumor patients who performed chemotherapy, we discussed the correlation between chemotherapy stomatitis and patient’s age, sex, tumor type, containing fluorouracil (5-FU) way of chemotherapy, the strength of chemotherapy, chemotherapy cycle, oral acute or chronic disease, oral hygiene status, the number of neutrophils, hemoglobin level, and whether associated with diabetes. Results: Univariate analysis showed that there were statistically significant differences in chemotherapy, intensity of chemotherapy, duration of chemotherapy, oral diseases, oral hygiene, and neutrophil levels. Further multivariate analysis showed that the intensity of chemotherapy drugs (β=1.099, P<0.05), duration of chemotherapy (β=0.964, P<0.05), mode of chemotherapy (β=1.100, P<0.05), acute and chronic diseases of the oral cavity (β=1.180, P<0.05), and number of neutrophils (β=1.050, P<0.05) were the main factors leading to chemotherapeutic stomatitis. Conclusion: The intensity and cycle of chemotherapeutic drugs, chemotherapy regimens, oral acute and chronic diseases, and neutrophil levels were risk factors for chemotherapeutic stomatitis.
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    Mandibular First Molar with Four Distal Canals: A Case Report
    FANG Yanjun, XUAN Hansheng, PAN Wan, LIANG Shanshan, MENG Liuyan
    2019, 35(8): 814-816.  DOI: 10.13701/j.cnki.kqyxyj.2019.08.022
    Abstract ( 303 )   PDF (5015KB) ( 213 )  
    Root canal system of mandibular first molar is very complicated. A mandibular first molar with four canals in distal root was considered to be a rare anatomical variant. This article described successful endodontic therapy of mandibular first molar with four distal canals reported for the first time in Chinese population.
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