Effect of Aspirin/Platelet-rich Fibrin Complex on Bone Restoration of Peri-implant Bone Defects

doi:10.13701/j.cnki.kqyxyj.2019.08.010

Abstract

Abstract: Objective: To evaluate the effect of Aspirin/platelet-rich fibrin (PRF) complex on repairing peri-implant bone defects in rats. Methods: A total of 30 male Sprague-Dawley rats (8 weeks of age) were used in the present study. 12 rats were used to prepare PRF and aspirin/PRF complex (100 mg/L) and 18 rats were used to prepare the peri-implant bone defects on both sides of tibia, and bone defects (1.5 mm×2.0 mm) were created along one distal bone wall of each implant sites. After implants placement, the rats were randomly divided into three groups: the bone defects in control group was left empty; the bone defects in PRF control group was implanted with PRF alone; and bone defects of aspirin/PRF complex group was implanted with aspirin/PRF complex. Three rats from each group were randomly sacrificed at 4 weeks and 8 weeks after implantation surgery. Specimens were subjected to general observation, bone histological observation, and histomorphometric analysis. Results: 4 weeks after implantation surgery, the implant bone contact rate in the aspirin/PRF complex group [(57.30±6.76)%] was significantly higher than that in the PRF control group [(45.93±6.53)%] and the control group [(27.35±10.31)%] (P＜0.05), and the implant bone contact rate in the PRF control group was also significantly higher than that in the control group (P＜0.05). The new bone areas percentage in the aspirin/PRF complex group [(24.34±6.11)%] was significantly higher than that in the PRF control group [(14.30±4.86)%] and the control group [(10.79±2.14)%] (P＜0.05). There was no statistical difference between PRF control group and control group (P>0.05). 8 weeks after implantation surgery, the implant bone contact rate in the aspirin/PRF complex group [(64.34±6.02)%] was significantly higher than that in the PRF control group [(52.62±6.08)%] and the control group [(54.32±6.57)%] (P＜0.05). There was no statistical difference between PRF control group and control group (P>0.05). In term of the new bone areas percentage, there was no statistical difference among aspirin/PRF complex group [(30.16±3.58)%], PRF control group [(26.27±5.36)%], and control group [(25.33±4.25)%] (P>0.05). Conclusions: Aspirin/PRF complex promotes bone regeneration in the bone defect area surrounding implant in the early stage of bone healing, shortens the implants and bone healing cycle, and improves the implants osseointegration.

Key words: Aspirin, platelet-rich fibrin, implant, bone regeneration

CHEN Rui, LI Fenglan. Effect of Aspirin/Platelet-rich Fibrin Complex on Bone Restoration of Peri-implant Bone Defects[J]. Journal of Oral Science Research, 2019, 35(8): 761-765.

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