Journal of Oral Science Research ›› 2019, Vol. 35 ›› Issue (12): 1129-1131.DOI: 10.13701/j.cnki.kqyxyj.2019.12.007

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Expression and Function of Splicing Factor hnRNP F in Head and Neck Squamous Cell Carcinoma

XIONG Yingjie, JIA Rong*   

  1. Hubei-MOST KLOS & KLOBME, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
  • Received:2019-06-05 Online:2019-12-28 Published:2019-12-23

Abstract: Objective: To investigate the expression and function of hnRNP F in head and neck squamous cell carcinoma (HNSCC). Methods: The expression of hnRNP F in head and neck squamous cell carcinoma was analyzed in TCGA and Oncomine database. The relationship between hnRNP F expression and disease-free survival in HNSCC was analyzed in cbioportal database. CAL-27 cells were transfected with anti-hnRNP F siRNA or non-specific siRNA. The growth curve of cells was analyzed by cell counting. Results: HnRNP F was overexpressed in HNSCC patients. Patients with high expression of hnRNP F showed significantly poorer disease-free survival than those with low expression of hnRNP F. Knockdown of hnRNP F significantly inhibited CAL-27 cell growth. Conclusion: hnRNP F may play important roles in the development of HNSCC.

Key words: head and neck squamous cell carcinoma, hnRNP F, RNA splicing