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Study on Relationship between Oxidative Stress and NF-κB-related Inflammatory Factors in Patients with Oral Lichen Planus
LI Xin, SUN Yinyin, PAN Yingxiao, WANG Sainan, ZHANG Xinyu, LU Shulai
2019, 35(12):
1187-1190.
DOI: 10.13701/j.cnki.kqyxyj.2019.12.021
Objective: To evaluate the oxidative stress status and NF-κB-related inflammatory factors of oral lichen planus patients by saliva samples, and to explore the correlation of them. Methods: Thirty patients with oral lichen planus(the OLP group)and 30 healthy people(the healthy controls)were selected. The OLP group was divided into non-erosive oral lichen planus (NEOLP) group and erosive oral lichen planus (EOLP) group. Indicators of oxidative stress MDA, 8-OHDG, TOS, TAC, and NF-κB related inflammatory factors IL-6, IL-8, and TNF-α were determined by using ELISA. Results: MDA, 8-OHDG, and TOS of OLP group, NEOLP group, and EOLP group were significantly higher than those of healthy people (P<0.05). TAC was significantly lower (P<0.05). The levels of TNF-α, IL-6, and IL-8 in OLP group, NEOLP group, and EOLP group were significantly higher than those in healthy controls (P<0.05). Compared with NEOLP group, MDA and 8-OHDG in EOLP patients increased (P<0.05), while TOC and TOS had no significant difference (P>0.05). There was no significant difference in TNF-α and IL-6 between EOLP patients and EOLP patients (P>0.05), but IL-8 increased significantly (P<0.05). TOS was positively correlated with TNF-α, IL-6, and IL-8 in OLP group, NEOLP group, and EOLP group (P<0.05),while TAC was negatively correlated with TNF-α, IL-6, and IL-8 (P<0.05). Conclusion: There was an increase in oxidative stress and the level of NF-κB related inflammatory factors in OLP patients, and there was a correlation between them.
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