Research Progress of Matrix Metalloproteinases in Caries

doi:10.13701/j.cnki.kqyxyj.2019.12.005

Abstract

Abstract: The proteolylic enzymes need Zn²⁺ and Ca²⁺ as cofactors, hence the name of matrix metalloproteinases(MMPs). Their family members can degrade most of the extracellular matrix. Type I collagen in dentin is also the substrate of MMPs. Most studies have shown that matrix metalloproteinases not only participate in maxillofacial neoplasms and mucosal diseases, but also participate in the pathological process of the soft and hard tissues of teeth, and periapical and periodontal lesions. MMPs have an vital function on the pathological changes of dental hard tissues and the process of restoration and treatment. MMPs can be detected, no matter whether it is sound or decayed dentin. This review has discussed the effect of MMPs in caries.

Key words: matrix metalloproteinases, caries, dentin, adhesive

LI Jingya, HUANG Yang. Research Progress of Matrix Metalloproteinases in Caries[J]. Journal of Oral Science Research, 2019, 35(12): 1122-1124.

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