Correlation between Invasive Depth of Gingival Squamous Cell Carcinoma and Lymph Node Metastasis

doi:10.13701/j.cnki.kqyxyj.2019.12.009

Abstract

Abstract: Objective: To analyze the correlation between infiltration depth and other related influencing factors and lymph node metastasis, and to determine whether the depth of invasion can be used as a predictor of lymph node metastasis. Methods: Thirty patients with gingival squamous cell carcinoma were enrolled in the study. 30 patients with preoperative lymph node negative (cN0) were enrolled in the study. The clinical factors (age, gender, T classification) and pathological factors (invasion depth, degree of differentiation, invasion mode, and peritumoral lymphocyte density) of gingival squamous cell carcinoma were reviewed. Results: Univariate logistic regression analysis showed that the depth of invasion and tumor invasion were correlated with lymph node metastasis. There was no significant correlation between gender, age, pathological grade, cTNM stage, and peritumoral lymphocyte infiltration density and lymph node metastasis. In multivariate logistic regression analysis, only the depth of invasion was an independent predictor of cervical lymph node metastasis. Conclusion: Invasion depth is an important factor in the regional lymph node metastasis of gingival squamous cell carcinoma. It is important for the evaluation of regional lymph node metastasis and can be used as a predictor of lymph node metastasis.

Key words: depth of invasion, lymph node metastasis, gingival squamous cell carcinoma

YU Ying, QU Weiguo, SU Yingying, ZHANG Qian, FENG Kai. Correlation between Invasive Depth of Gingival Squamous Cell Carcinoma and Lymph Node Metastasis[J]. Journal of Oral Science Research, 2019, 35(12): 1137-1140.

References

[1] Tarsitano A, Del Corso G, Tardio ML, et al. Tumor infiltration depth as predictor of nodal metastasis in early tongue squamous cell carcinoma [J]. J Oral Maxillofac Surg, 2016, 74(3):523-527.
[2] 贾宝超, 关键, 戴辛鹏, 等. Nrf2、HO-1在口腔鳞癌组织中的表达及其临床意义[J]. 口腔医学研究, 2017, 33(2): 207-210.
[3] Lydiatt WM, Patel SG, O'Sullivan B, et al. Head and neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual [J]. CA Cancer J Clin, 2017, 67(2):122-137.
[4] Keski-Säntti H, Atula T, Tikka J, et al. Predictive value of histopathologic parameters in early squamous cell carcinoma of oral tongue [J]. Oral Oncol, 2007, 43(10):1007-1013.
[5] Hegde P, Roy S, Shetty T, et al. Tumor infiltration depth as a prognostic parameter for nodal metastasis in oral squamous cell carcinoma[J]. Int J Appl Basic Med Res, 2017, 7(4): 252-257.
[6] Pentenero M, Gandolfo S, Carrozzo M. Importance of tumor thickness and depth of invasion in nodal involvement and prognosis of oral squamous cell carcinoma: a review of the literature [J]. Head Neck, 2005, 27(12):1080-1091.
[7] Moore C, Kuhns JG, Greenberg RA. Thickness as prognostic aid in upper aerodigestive tract cancer [J]. Arch Surg, 1986, 121(12):1410-1414.
[8] Gonzalez-Moles MA, Esteban F, Rodriguez-Archilla A, et al. Importance of tumour thickness measurement in prognosis of tongue cancer [J]. Oral Oncol, 2002, 38(4): 394-397.
[9] 贺智凤,蒲玉梅,胡勤刚. 口腔鳞状细胞癌切缘状态评估及其影响因素分析[J]. 中华口腔医学杂志,2017, 52(7):445-449.
[10] Melchers LJ, Schuuring E, van Dijk BA, et al. Tumour infiltration depth ≥4 mm is an indication for an elective neck dissection in pT1cN0 oral squamous cell carcinoma [J]. Oral Oncol, 2012, 48(4): 337-342.
[11] Wermker K, Belok F, Schipmann S, et al. Prediction model for lymph node metastasis and recommendations for elective neck dissection in lip cancer [J]. J Craniomaxillofac Surg, 2015, 43(4): 545-552.
[12] Brockhoff HC 2nd, Kim RY, Braun TM, et al. Correlating the depth of invasion at specific anatomic locations with the risk for regional metastatic disease to lymph nodes in the neck for oral squamous cell carcinoma [J]. Head Neck, 2017, 39(5): 974-979.
[13] Larry J Peterson. Peterson口腔颌面外科学[M].Michael Miloro, 蔡志刚,译.第2版. 北京:人民卫生出版社,2011:596-598.
[14] Goerkem M, Braun J, Stoeckli SJ. Evaluation of clinical and histomorphological parameters as potential predictors of occult metastases in sentinel lymph nodes of early squamous cell carcinoma of the oral cavity [J]. Ann Surg Oncol, 2010, 17(2): 527-535.