Effectiveness of Oral and Intramuscular Midazolam in Treatment of Pediatric Dental Anxiety

doi:10.13701/j.cnki.kqyxyj.2021.02.013

Abstract

Abstract: Objective: To evaluate the sedative effect of midazolam on dental anxiety in children treated with oral or intramuscular rout. Methods: From January 2020 to July 2020, 90 children who received midazolam sedation in the Stomatology Department of Shenzhen Children's Hospital were randomly divided into two groups, 45 in each group. Midazolam was given intramuscularly (0.2 mg/kg) in the intramuscular group and orally (0.6 mg/kg, maximum single dose 20.0 mg). Sedation effectiveness was assessed with the Ramsay Scale, treatment compliance with the Frankl Scale, and treatment completion with the Houpt Scale. At the same time, the onset time of drugs, heart rate, blood oxygen saturation, and intraoperative and postoperative adverse reactions were recorded. Results: The onset time of the intramuscular group (13.0±2.0min) was significantly shorter than that of oral group (15.6±1.8min, P<0.05). The median scores of the Ramsay (Z=-1.089, P=0.276), Frankl (Z=-0.0863, P=0.388), and Houpt scales (Z=-1.854, P=0.064) were not statistically significant, and the distribution of scores was similar (P<0.05). There was no significant difference in the sedation success rate (χ²=0.178, P>0.05) and treatment success rate(χ²=3.103, P>0.05) between two groups. And there was no significant difference in the incidence of side effects(χ²=0.080, P>0.05). Conclusions: Oral or intramuscular midazolam has similar sedative effectiveness, and both of them are safe and effective sedation methods in the treatment of dental anxiety in children, but the onset time of sedation is shorter in the intramuscular injection group.

Key words: dental anxiety, midazolam, sedation, pediatric dentistry

NIE Juan, CHEN Chanchan, XIE Jing, LI Chenxi, LIU Zifeng, DING Guicong. Effectiveness of Oral and Intramuscular Midazolam in Treatment of Pediatric Dental Anxiety[J]. Journal of Oral Science Research, 2021, 37(2): 148-152.

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