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18 February 2021, Volume 37 Issue 2 Previous Issue    Next Issue

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Gut Microbiota in Interaction Effects of Periodontitis and Hyperlipidemia YAN Fuhua, HUANG Yuezhen 2021, 37(2): 95-100.  DOI: 10.13701/j.cnki.kqyxyj.2021.02.001 Abstract ( 295 )   PDF (1022KB) ( 444 )   Periodontitis and hyperlipidemia are common chronic diseases that seriously affect human health. It is reported that there is a positive relationship between them. However, the exact biological mechanisms are still unclear. Intestinal microecosystem is the largest and most complex ecosystem in human body. Multiple studies have confirmed that the gut microbiota can regulate blood lipids and bone metabolism through its own metabolites, affecting host metabolism and immune response. Both periodontitis and hyperlipidemia can cause changes in the composition of intestinal microbiota. This review aims to deliver an overview of the interaction effects of periodontitis and hyperlipidemia via gut microbiota and provide some new ideas and theoretical bases to improve the recognition of relationship between two diseases. References | Related Articles | Metrics

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Research Progress on Correlation between Entamoeba Gingivalis and Periodontitis JIAO Junwei, ZHAO Lei 2021, 37(2): 101-104.  DOI: 10.13701/j.cnki.kqyxyj.2021.02.002 Abstract ( 266 )   PDF (784KB) ( 321 )   The protozoan Entamoeba gingivalis, commonly resided in the oral cavity and pharynx, is the first described amoeba in human. Entamoeba gingivalis frequently presents a significantly higher prevalence in patients with poor oral hygiene or some oral diseases, especially in the periodontal pockets of periodontitis. Although this species of Entamoeba used to be regarded as a symbiotic microorganism, with the continuous development of detection and analysis techniques, studies in recent years have shown that there may be a close relationship between Entamoeba gingivalis and periodontitis. This article reviews the research progress on the correlation between Entamoeba gingivalis and periodontitis. References | Related Articles | Metrics

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Effect of Low-magnitude High-frequency Vibration Loading on Osseointegration: An Update YE Xinjian, WANG Shuhua 2021, 37(2): 105-108.  DOI: 10.13701/j.cnki.kqyxyj.2021.02.003 Abstract ( 226 )   PDF (799KB) ( 281 )   Low-magnitude high-frequency vibration (LMHFV), as a short term, simple, clean and less adverse reactions physiotherapy, has been proved to show a strong osteogenic effect. LMHFV plays an active role in bone remodeling in various parts of the body. And it is reported that LMHFV has a positive effect on peri-implant bone healing and osseointegration. In this paper, the mechanism of LMHFV, the transmission mechanism of LMHFV, the effect of LMHFV on bone growth around implants, and the safety of LMHFV are briefly reviewed, and the prospect is put forward with hope to apply LMHFV in the clinic efficiently. References | Related Articles | Metrics

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Effects of Oxidative Stress on Oral Potentially Malignant Disorders SHA Tong, ZHANG Wei 2021, 37(2): 109-112.  DOI: 10.13701/j.cnki.kqyxyj.2021.02.004 Abstract ( 225 )   PDF (1382KB) ( 261 )   Oral potentially malignant disorders (OPMD) are clinical presentations that carry a risk of cancer development in the oral cavity, and its pathogenesis is still unclear. Studies have shown that oxidative stress (OS) is associated with the lipid peroxidation and DNA damage and the imbalance of antioxidant system in patients with oral lichen planus, oral leukoplakia, and oral submucosal fibrosis. The oxidative damage caused by reactive oxygen species (ROS) is closely related to the occurrence and development of them. Through the research of OS and these diseases, the pathogenesis of OS can be further clarified and new ideas for the prevention and antioxidant treatment of the disease can be provided. References | Related Articles | Metrics

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Research Progress on Regulation and Mechanism of microRNA on Dental Pulp Stem Cell Differentiation ZHAO Yun, MI Fanglin 2021, 37(2): 113-117.  DOI: 10.13701/j.cnki.kqyxyj.2021.02.005 Abstract ( 224 )   PDF (797KB) ( 336 )   Dental pulp stem cells are stem cells derived from neural crest with good self-renewal and multi-directional differentiation characteristics. They can differentiate into a variety of oral tissue related cells with low immunogenicity. It has been widely used as seed cells in tissue engineering and regenerative medicine fields. MicroRNA is a kind of short chain non-coding RNA that regulates the expression of target genes by acting on post-transcriptional RNA, which plays an important role in all aspects of life activities, such as cell growth, cell proliferation, embryonic development, tissue differentiation, and apoptosis. In this paper, we review the regulatory role and mechanism of microRNA in the differentiation of dental pulp stem cells. References | Related Articles | Metrics

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Effect of Preparation Designs on Fracture Strengths of Endocrown of Maxillary Short Coronal Molars SU Meng, QU Zhi 2021, 37(2): 118-121.  DOI: 10.13701/j.cnki.kqyxyj.2021.02.006 Abstract ( 182 )   PDF (1567KB) ( 305 )   Objective: To evaluate the effect of restoration design with different preparation depths and with or without ferrule on the failure load of maxillary short coronal molar restored with endocrown. Methods: Thirty permanent molars with complete morphology from the neck to the apical were collected. Three kinds of pulp cavity preparation depth, i.e. 3 mm, 4 mm, and 5 mm and two kinds of margin design were randomly divided into six groups, which were restored with zirconia endocrowns by CAD-CAM technique. The flexural strength test was recorded with the fracture load value and the fracture mode. Results: No matter the butt margin group or the shoulder group, the maximum loading value of the six groups was 3mm<4mm<5mm, however, there was no significant difference between two groups. The maximum load value of the shoulder group was greater than that of the butt margin group, and there was a statistically significant difference between the 3mm and 4mm groups. In the fracture mode of six groups of samples, irremediable fracture was the main one, and all samples in the 5mm group presented irremediable fracture. Conclution: When maxillary short coronal molars were restored with zirconia endocrowns by CAD-CAM technology, the preparation depth of pulp cavity at 3mm and 4mm could meet the requirements of clinical flexural strength, however, no more than 4mm. In addition, the introduction of 1mm dentin shoulder collar could be used as a clinical preparation method to effectively increase the flexural strength of teeth and prostheses. References | Related Articles | Metrics

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Regulation of Phosvitin on Remineralization of Demineralized Dentin by Bioactive Glass YU Shaoling, ZANG Ruijue, LI Heng 2021, 37(2): 122-125.  DOI: 10.13701/j.cnki.kqyxyj.2021.02.007 Abstract ( 140 )   PDF (3190KB) ( 244 )   Objective: To investigate the regulation of phosvitin (PV) on remineralization of demineralized dentin by bioactive glass (BG). Methods: 120 dentin slices were prepared and randomly divided into 6 groups: Group A was treated with SBF as the control group, Group B was treated with 100 mg/L PV, Group C was treated with 500 mg/L PV, Group D was treated with SBF and BG, Group E was treated with 100 mg/L PV and BG, and Group F was treated with 500 mg/L PV and BG. After simulated oral temperature treatment for 30 days, the microstructure of dentin surface was observed by scanning electron microscope (SEM) and the values of surface microhardness (SMH) was measured. Results: The SMH values of group E and F were significantly different from those of other groups(P＜0.01),but there was no significant difference between two groups(P＞0.05). SMH value of group C or D was significantly different from that of group A(P＜0.05). Remineralization were observed in all groups, and the sediments of group E and F were more uniform and tighter. Conclusion: PV can promote the remineralization on the dentin surface, and the combination of PV and BG achieves the synergistic effect. References | Related Articles | Metrics

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Effect of Concentrations and Action Time of Sodium Hypochlorite (NaClO) Solution on Resin-dentin Bonding Interface WANG Luyao, SHEN Shuai, NIU Yumei, PAN Shuang 2021, 37(2): 126-130.  DOI: 10.13701/j.cnki.kqyxyj.2021.02.008 Abstract ( 164 )   PDF (1153KB) ( 254 )   Objective: To investigate the influence of different concentrations and time of sodium hypochlorite (NaClO) solution on the resin-dentin bonding interface. Methods: Fifty human molars were selected to remove the tooth root and occlusal enamel, and exposed the dentin layer. A 4mm thick composite resin block was piled on the bonding surface. Teeth were sectioned vertically along two perpendicular directions into beams of approximately 1.0 mm2 in cross-section. Fifty specimens were randomly divided into five groups: Group C (control), Group A1 (2.5%NaClO solution for 1 hour), Group A2 (2.5%NaClO solution for 2 hours), Group B1 (5.25%NaClO solution for 1 hour), and Group B2 (5.25%NaClO solution for 2 hours). The microtensile bond strength (μTBS) of five groups was tested. The stereomicroscope and SEM images of the fractured areas were used to determine the fracture mode of specimens. Results: The microtensile strength values of four experimental groups were significantly reduced compared to the control group with the increase of the concentration and the action time of NaClO solution. The action time of NaClO solution had no significant effects on the resin dentin bonding strength (P>0.05). The concentration of NaClO solution had no significant effects on the dentin bonding strength of the resin (P>0.05). However, there was an interaction effect between the concentration and action time of NaClO solution (P<0.05). Scanning electron microscope and stereo microscope showed that five groups of samples mainly fractured at the bonding interface. Conclusion: The micro-tensile bonding strength of the adhesion interface between dentin and resin can be reduced with the increase of concentration and action time of NaClO solution. References | Related Articles | Metrics

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Evaluation of Antibacterial Ability of Epigallocatechin-3-gallate-modified Adhesive YANG Liuqing, Wang Bohao, XIE Lili 2021, 37(2): 131-134.  DOI: 10.13701/j.cnki.kqyxyj.2021.02.009 Abstract ( 184 )   PDF (1519KB) ( 231 )   Objective: To evaluate the antibacterial and bonding performance of adhesives incorporated with different concentrations of epigallocatechin-3-gallate (EGCG), and provide experimental support for the usage in preventing the occurrence of white spot lesions in orthodontic treatment. Methods: Four experimental groups were designed, namely 0 (Control group), 0.1, 1.0, and 10 g/L EGCG groups. The antibacterial ability of experimental adhesives was assessed by live/dead bacterial staining and MTT assay. The shear bond strength (SBS) and degree of conversion (DC) were evaluated to assess the bonding performance of experimental adhesives. Results: Comparing with the Control group, the incorporation of EGCG into adhesive significantly increased the antibacterial ability (P<0.05), which had positive correlation with EGCG concentration. No negative influence on the SBS and DC was detected for 0.1 and 1.0 g/L EGCG groups (P>0.05), but the value of 10 g/L EGCG group significantly decreased (P<0.05). Conclusion: The addition of 1.0 g/L EGCG into dental adhesive could exert positive antibacterial ability without hampering the polymerization of dental adhesive. References | Related Articles | Metrics

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Clinical Application of PLA Absorbable Root Canal Post Combined with Cyanoacrylate Adhesive in Residual Crown of Infant Anterior Teeth QI Fengna, SUN Honglei, XU Hua, LI Junke, CHENG Ruiqing 2021, 37(2): 135-138.  DOI: 10.13701/j.cnki.kqyxyj.2021.02.010 Abstract ( 192 )   PDF (1336KB) ( 252 )   Objective: To study the application of polylactic acid (PLA) absorbable root canal post combined with cyanoacrylate adhesive in the restoration of infant anterior crown. Methods: A total of 100 infants with anterior residual crown admitted to our hospital from January 2017 to December 2018 were selected and randomly divided into control group and PLA group with 50 cases each. The control group was repaired with glass fiber short post combined with double curing resin adhesive, while the PLA group was repaired with PLA absorbable root pipe post combined with cyanoacrylate adhesive. The gingival condition, occlusal function, gingival sulcus inflammation, and clinical efficacy of two groups were evaluated, and the incidence of adverse events was followed up. Results: The gingival index and bite force after repair were higher than those before repair, and the gingival bleeding index was lower than that before repair. In addition, the gingival index and bite force of the PLA group were higher than those of the control group, and the gingival bleeding index was lower than that of the control group (P<0.05). After repair, the levels of TNF-α, CRP, IL-8, and IL-6 in the PLA group were all lower than those in the control group (P<0.05). The success rate of repair in PLA group was significantly higher than that in control group (P<0.05). The total incidence of adverse events in PLA group was significantly lower than that in the control group (P<0.05). Conclusion: PLA absorbable root canal post combined with cyanoacrylate adhesive can improve gingival state, inhibit the expression of TNF-α, CRP, IL-8, IL-6, and other inflammatory indexes in the treatment of residual crown of anterior teeth in infants, which has less stimulation to gingiva, reduces the occurrence of adverse events, and has a high success rate of restoration. References | Related Articles | Metrics

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Mechanical Properties of Polylactic Acid Composites and Root Dentin of Primary Anterior Teeth GAO Li, WANG Rui, ZHANG Hui, LIU Wentao, MA Ning 2021, 37(2): 139-143.  DOI: 10.13701/j.cnki.kqyxyj.2021.02.011 Abstract ( 163 )   PDF (1179KB) ( 151 )   Objective: To test the mechanical properties of different proportions of polylactic acid/hydroxyapatite (PLLA/HA) composites and root dentin of primary anterior teeth. Methods: PLLA/HA composites with different proportions were prepared by melt blending method. PLLA/HA composites were divided into PLLA, PLLA-1%HA, PLLA-3%HA, PLLA-5%HA, and PLLA-7%HA groups according to different HA mass percentages. The tensile and flexural properties were tested by electronic universal tester, and the impact strength of the composites was tested by pendulum impact tester. 16 primary anterior teeth were collected in vitro, and the compressive modulus and strength of root dentin were tested. Results: There was no significant difference in flexural modulus and impact strength among the five groups (P>0.05), but there were significant differences in tensile strength and flexural strength (P<0.05). The tensile strength and flexural strength of PLLA/HA composites in PLLA-1%HA, PLLA-3%HA, and PLLA-5%HA groups were lower than those in PLLA group, but there was no significant difference among three groups (P>0.05). The mean compressive modulus and strength of the root dentin were 3.63 GPa and 128.03 MPa, respectively. Conclusion: PLLA-1%HA, PLLA-3%HA, and PLLA-5%HA composites are expected to be the materials of root canal post in primary teeth due to the certain mechanical properties, but their mechanical properties need to be further improved. References | Related Articles | Metrics

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Study on Recovery Quality and Related Influencing Factors after Pediatric Dental Therapy under Ambulatory General Anesthesia LIU Bing, FENG Caihua, ZHANG Guoliang, ZHANG Yaqiu, LIANG Lirong, WANG Peijuan, YAN Wei, ZHANG Hui 2021, 37(2): 144-147.  DOI: 10.13701/j.cnki.kqyxyj.2021.02.012 Abstract ( 191 )   PDF (756KB) ( 122 )   Objective: To explore the recovery quality and related influencing factors of pediatric dental therapy under ambulatory general anesthesia. Methods: A total of 418 children, aged 2-6 years old, American Society of Anesthesiologists physical status being Ⅰ or Ⅱ, with dental caries receiving dental therapies under ambulatory general anesthesia were included. Scoring system for sore throat, cough, hoarseness, and post-operative quality recovery scale were used to evaluate the recovery quality 24 h after general anesthesia. The recovery of each item after anesthesia was analyzed. Meanwhile five possible related influencing factors were analyzed, including gender, age, duration of anesthesia, number of teeth treated, and dosage of sevoflurane. Results: The sore throat, cough, and hoarseness were mainly mild at 24 h after general anesthesia, the incidences were 18.4%, 22.3%, and 23% respectively. The incidence of mild and moderate postoperative nausea and vomiting (PONV) were 8.4% and 0.2%, respectively. The incidences of mild, moderate, and severe toothache were 44.0%, 13.2%, and 0.9%, respectively. The incidence of mild depression and anxiety were 30.4% and 19.9%. There were significant differences in cough and PONV between different genders (P<0.05). There were significant differences in PONV and depression among different anesthesia duration groups (P<0.05). There were significant differences in sore throat and hoarseness among different number of teeth treated groups (P<0.05). There was no statistical significance in the different age groups and sevoflurane dosage groups. Conclusion: Gender, anesthesia duration, and number of teeth treated have some influence on the recovery of children receiving pediatric dental therapy under ambulatory general anesthesia. There is still some room for the improvement of the recovery quality after pediatric dental therapy under ambulatory general anesthesia. References | Related Articles | Metrics

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Effectiveness of Oral and Intramuscular Midazolam in Treatment of Pediatric Dental Anxiety NIE Juan, CHEN Chanchan, XIE Jing, LI Chenxi, LIU Zifeng, DING Guicong 2021, 37(2): 148-152.  DOI: 10.13701/j.cnki.kqyxyj.2021.02.013 Abstract ( 158 )   PDF (923KB) ( 171 )   Objective: To evaluate the sedative effect of midazolam on dental anxiety in children treated with oral or intramuscular rout. Methods: From January 2020 to July 2020, 90 children who received midazolam sedation in the Stomatology Department of Shenzhen Children's Hospital were randomly divided into two groups, 45 in each group. Midazolam was given intramuscularly (0.2 mg/kg) in the intramuscular group and orally (0.6 mg/kg, maximum single dose 20.0 mg). Sedation effectiveness was assessed with the Ramsay Scale, treatment compliance with the Frankl Scale, and treatment completion with the Houpt Scale. At the same time, the onset time of drugs, heart rate, blood oxygen saturation, and intraoperative and postoperative adverse reactions were recorded. Results: The onset time of the intramuscular group (13.0±2.0min) was significantly shorter than that of oral group (15.6±1.8min, P<0.05). The median scores of the Ramsay (Z=-1.089, P=0.276), Frankl (Z=-0.0863, P=0.388), and Houpt scales (Z=-1.854, P=0.064) were not statistically significant, and the distribution of scores was similar (P<0.05). There was no significant difference in the sedation success rate (χ2=0.178, P>0.05) and treatment success rate(χ2=3.103, P>0.05) between two groups. And there was no significant difference in the incidence of side effects(χ2=0.080, P>0.05). Conclusions: Oral or intramuscular midazolam has similar sedative effectiveness, and both of them are safe and effective sedation methods in the treatment of dental anxiety in children, but the onset time of sedation is shorter in the intramuscular injection group. References | Related Articles | Metrics

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Effect of Two Different General Anesthesia Methods on Immune Function of Oral Squamous Cell Carcinoma Patients: A Randomized Controlled Study YIN Fang, LI Jinjie, GONG Ping, ZHOU Tengpeng, LIU Kebin, ZHANG Tiejun 2021, 37(2): 153-156.  DOI: 10.13701/j.cnki.kqyxyj.2021.02.014 Abstract ( 154 )   PDF (760KB) ( 104 )   Objective: To evaluate the effects of two different general anesthesia methods on perioperative immune function of patients undergoing radical treatment of oral squamous cell carcinoma and immediate repair of free flap defect. Methods: A total of 40 patients with oral squamous cell carcinoma who underwent elective surgery were enrolled and randomly divided into group DP and group S (n=20). In group DP, dexmedetomidine and propofol were used as main anesthetics, and in Group S, sevoflurane was used as the main anesthetic. Other anesthetics were the same in both groups. Venous blood samples were taken at six time-points: 30 minutes before anaesthesia (T0), 3 hours after anaesthesia (T1), at the end of the operation (T2); and 6 hours (T3), 24 hours (T4) and 48 hours (T5) after operation. The serum concentrations of immunoglobulin (IgA, IgM, IgG) and immunocytokines (IL-2, IL-6, IL-10, sIL-2Rα) were measured. Results: All indicators were statistically different from T0 at multiple time points within groups (P<0.05), but immunoglobulins were not statistically different between two groups, while immunocytokines were statistically different between two groups except T0 (P<0.05). At T4 and T5, the concentrations of sIL-2Rα and IL-6 in Group S were higher than those in group DP, while the concentration of IL-2 in group S was lower than that in group DP (P<0.05). The concentration of IL-10 in Group S was higher than that in group DP at T1 to T4 (P<0.05). Conclusion: There was no statistical difference on immuneglobulins related to humoral immunity in patients under different general anesthesia methods. However, the level of IL-2, IL-6, IL-10, and sIL-2Rα in circulation can be better maintained by intravenous anesthesia based on propofol and dexmedetomidine, which may be more helpful to relieve the immune suppression induced by surgery. References | Related Articles | Metrics

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Dimensional Variations and Spatial Distribution Regularities of Mandibular Incisive Canal and Its Impact on Safe Range of Bone Harvesting YU Ti, ZHOU Qiao, HUANG Yuanding, JI Ping, HUANG Hong 2021, 37(2): 157-161.  DOI: 10.13701/j.cnki.kqyxyj.2021.02.015 Abstract ( 180 )   PDF (2314KB) ( 178 )   Objective: To assess the dimensional variations and spatial distribution regularities of mandibular incisive canal (MIC) by means of CBCT, and to demonstrate its impact on safe range of bone harvesting. Methods: 160 semi-mandibles of 80 patients were recruited in this study. The CBCT data were reconstructed to evaluate the visibility, diameter, and location within the mandible of MIC. Results: The rate of the MIC identification had a range of 52.5%-77.4%, showing an upward tendency from the central incisor to the first premolar. The mean distance from MIC to the labial cortex were (3.74±1.23) mm in straight line and (3.54±1.18) mm in tangential direction respectively (P＜0.005). Conclusion: The MIC runs slightly downward from the foramen to the midline, with its diameter and visibility decreasing. It locates closer to the labial cortex as constantly as (3.54±1.18) mm in different tooth sites but remains below the link line of bilateral mental foramens with different level ranging from (3.79±1.78) mm to (8.41±2.91) mm. The harvesting of bone graft in the interforaminal region should be limited within the distance range. References | Related Articles | Metrics

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Imaging Evaluation and Clinical Controlled Study of Bone Augmentation with CGF in Lateral Maxillary Sinus Floor Augmentation LIU Ruimin, YAN Mingdong, HUANG Wenxiu, WU Dong, CHEN Jiang 2021, 37(2): 162-166.  DOI: 10.13701/j.cnki.kqyxyj.2021.02.016 Abstract ( 224 )   PDF (3966KB) ( 275 )   Objective: To explore the clinical efficacy of CGF combined with bone substitute material in maxillary sinus augmentation and the imaging changes by Mimics software. Methods: The patients were divided into two groups: experimental group (10 cases, CGF combined with bone substitute group) and control group (10 cases, only using bone substitute group). After introducing the CBCT data of the day and 6 months after lateral sinus lift into Mimics 19.0 software, the short-term bone resorption rate and the increased multiple of bone mineral density were calculated. Complications, postoperative satisfaction (VAS), and survival rate were evaluated. Results: During the follow-up period, all 20 patients achieved positive results. Imaging examination: the average bone resorption rate of the experimental group was significantly higher than that of the control group (P<0.05). The average bone mineral density of the experimental group was significantly higher than that of the control group (P<0.05). Conclusion: The combination of CGF and bone substitutes can achieve good clinical effect in the treatment of severe bone deficiency in the posterior maxillary region, and the addition of CGF can increase the density of bone tissue in maxillary sinus, but its long-term effect needs further follow-up. References | Related Articles | Metrics

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Shixin Buccal Tablets on Recurrent Aphthae with Syndrome of Flaring Up of the Stomach-fire: A Randomized Double-blind Placebo-controlled Multicenter Clinical Trial TIAN Yuan, ZHOU Gang, GUAN Xiaobing, TAN Jin, LIU Guanjian, SUI Qiuli, LI Jia, LIN Mei, ZHOU Hongmei 2021, 37(2): 167-172.  DOI: 10.13701/j.cnki.kqyxyj.2021.02.017 Abstract ( 249 )   PDF (964KB) ( 249 )   Objective: To study the efficacy and safety of Shixin buccal tablets on the treatment of recurrent aphthae with syndrome of flaring up of the stomach-fire. Methods: A randomized, double-blind, placebo controlled, parallel-group, and multicenter study with single simulation was conducted. The patients in experimental group and the control group were given Shixin buccal tablets and placebo respectively for 5 days. The clinical outcomes consisted of the primary outcome (onset time of pain relief) and the secondary outcomes (rate of ulcer healing, days for ulcer healing, numbers of ulcers, pain scores,size of ulcers and the traditional Chinese medicine(TCM)symptoms of measurements). Adverse events and laboratory results were recorded to evaluate the safety of the agent. Results: 234 patients were enrolled and randomly divided into the experimental group and the control group, with 117 cases each. The primary outcome,namely,onset time of pain relief in experimental group was shorter than that in the control group (P<0.05). For all secondary outcomes,the experimental group showed significantly better efficacy than that in the control group (P<0.01). The main adverse reactions were mild gastrointestinal symptoms such as stomachache or diarrhea,which could be relieved without any treatment. No severe adverse events were observed. The incidence of adverse events and adverse reactions was similar between two groups. Conclusion:Shixin buccal tablets is effective and safe on the treatment of recurrent aphthae with syndrome of flaring up of the stomach-fire. References | Related Articles | Metrics

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Clinical Analysis of Thirty-one Cases of IgG4-related Disease PU Jiao, HU Lulu, NIU Yaqi, JIA Mengying, ZENG Xuemin, HE Wei, GONG Zhongcheng 2021, 37(2): 173-178.  DOI: 10.13701/j.cnki.kqyxyj.2021.02.018 Abstract ( 160 )   PDF (2950KB) ( 176 )   Objective: To improve the understanding, diagnosis, and treatment of IgG4-RD. Methods: The clinical, imaging, serological, pathological, and therapeutic features of 31 patients with IgG4-RD diagnosed in the first affiliated Hospital of Xinjiang Medical University were analyzed, and IgG4-RD responder index was used to evaluate disease activity and damage. Results: Among the 31 patients, there were 18 males and 13 females, with an average age of (59.1±9.12) years. The median time from onset to diagnosis was 10 months (range 1-120 months). Six cases were misdiagnosed at the first diagnosis, with a misdiagnosis rate of 19.35%. 32.26% of the patients were complicated with allergic diseases. Imaging revealed that all patients had organ occupying, and all patients had 2 or more organs involved, mainly salivary gland (77.42%), followed by lymph nodes, lacrimal gland, bile duct, and so on. The IgG4-RD responder index was 7.13±3.25, and it was positively correlated with the involved organs (r=0.15, P<0.0001). Serum IgG4 increased in 93.55% of these patients, and it was positively correlated with serum IgG (r=0.54, P<0.01). Histopathology showed infiltration of lymphatic plasma cells, obvious proliferation of lymphoid follicles and irregular fibrosis between tissues. Among the 25 patients who took glucocorticoid drugs, one patient was treated with rituximab because of ineffective treatment, and two patients were treated with immunosuppressants. The follow-up time was (25.89±14.02) months. Twelve patients had good results after treatment, the level of IgG4 decreased. Twelve patients had recurrence during treatment, with a recurrence rate of 48%. One case died of heart attack during treatment. Conclusion: IgG4-RD is a multi-system fibro-inflammatory disease, which is common in middle-aged and elderly men. Enlargement of salivary glands, lymph nodes, lacrimal glands, and internal organs is a common clinical manifestation. Glucocorticoids and biological agents are effective in the treatment, but there is a recurrence. References | Related Articles | Metrics

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Successful Treatment of Oral mucosa Multiple Papillomatosis with Photodynamic Therapy: One Case Report GAO Xin, CHENG Yingjie, CUI Jiantong, GAN Dian, WANG Xinwen 2021, 37(2): 179-180.  DOI: 10.13701/j.cnki.kqyxyj.2021.02.019 Abstract ( 160 )   PDF (1780KB) ( 326 )   This case report showed successful treatment of an oral mucosa multiple papillomatosis with photodynamic therapy. The clinical procedure showed the potential outcome and feasibility of photodynamic therapy in the treatment of oral mucosa diseases. References | Related Articles | Metrics