Effect of Two Different General Anesthesia Methods on Immune Function of Oral Squamous Cell Carcinoma Patients: A Randomized Controlled Study

doi:10.13701/j.cnki.kqyxyj.2021.02.014

Abstract

Abstract: Objective: To evaluate the effects of two different general anesthesia methods on perioperative immune function of patients undergoing radical treatment of oral squamous cell carcinoma and immediate repair of free flap defect. Methods: A total of 40 patients with oral squamous cell carcinoma who underwent elective surgery were enrolled and randomly divided into group DP and group S (n=20). In group DP, dexmedetomidine and propofol were used as main anesthetics, and in Group S, sevoflurane was used as the main anesthetic. Other anesthetics were the same in both groups. Venous blood samples were taken at six time-points: 30 minutes before anaesthesia (T0), 3 hours after anaesthesia (T1), at the end of the operation (T2); and 6 hours (T3), 24 hours (T4) and 48 hours (T5) after operation. The serum concentrations of immunoglobulin (IgA, IgM, IgG) and immunocytokines (IL-2, IL-6, IL-10, sIL-2Rα) were measured. Results: All indicators were statistically different from T0 at multiple time points within groups (P<0.05), but immunoglobulins were not statistically different between two groups, while immunocytokines were statistically different between two groups except T0 (P<0.05). At T4 and T5, the concentrations of sIL-2Rα and IL-6 in Group S were higher than those in group DP, while the concentration of IL-2 in group S was lower than that in group DP (P<0.05). The concentration of IL-10 in Group S was higher than that in group DP at T1 to T4 (P<0.05). Conclusion: There was no statistical difference on immuneglobulins related to humoral immunity in patients under different general anesthesia methods. However, the level of IL-2, IL-6, IL-10, and sIL-2Rα in circulation can be better maintained by intravenous anesthesia based on propofol and dexmedetomidine, which may be more helpful to relieve the immune suppression induced by surgery.

Key words: anesthesia, oral squamous cell carcinoma, immunity

YIN Fang, LI Jinjie, GONG Ping, ZHOU Tengpeng, LIU Kebin, ZHANG Tiejun. Effect of Two Different General Anesthesia Methods on Immune Function of Oral Squamous Cell Carcinoma Patients: A Randomized Controlled Study[J]. Journal of Oral Science Research, 2021, 37(2): 153-156.

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