Change of TGF-β+ Regulatory B Cells during Periodontitis

doi:10.13701/j.cnki.kqyxyj.2020.02.011

Abstract

Abstract: Objective: To explore the change of TGF-β⁺ regulatory B cells during periodontitis, and to find out its possible mechanism. Methods: Experimental periodontitis animal model using SD rats was set. The animals were sacrificed after 28 days. The gingiva and peripheral blood were obtained for further research. The proportion of TGF-β⁺ regulatory B cells was detected by flow cytometry. The expression of BAFF, APRIL, and IL-33 were analyzed by real time PCR. Results: In comparison with healthy animals, the proportion of TGF-β⁺ regulatory B cells in periodontitis ones were significantly higher (P<0.05). However, in the peripheral blood, they were similar (P>0.05). Compared with healthy ones, the expression of BAFF, APRIL, and IL-33 in the gingiva were significantly higher in the periodontitis group. However, in the peripheral blood, there was no significant difference. Conclusion: The higher proportion of TGF-β⁺ regulatory B cells detected in gingiva of periodontitis animals may relate to the increased expression of local BAFF, APRIL, and IL-33.

Key words: periodontitis, regulatory B cells, host immunity, interleukin-33, transforming growth factor-β

HAN Yakun, YU Chengcheng, YU Yan. Change of TGF-β⁺ Regulatory B Cells during Periodontitis[J]. Journal of Oral Science Research, 2020, 36(2): 135-138.

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Change of TGF-β⁺ Regulatory B Cells during Periodontitis

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