Research Progress of Small Molecule Compounds Against Dental Plaque Biofilm

doi:10.13701/j.cnki.kqyxyj.2021.03.005

Abstract

Abstract: Dental plaque biofilm is the main cause of dental caries and periodontal diseases. The resistance of bacteria in biofilm to antibiotics and host defense is higher than that of planktonic bacteria. There are many shortcomings in the traditional methods to remove biofilm, so the research focus turns to small molecule compounds because they are cell permeable and easily synthesized. The small molecule antibiofilm compounds can be roughly divided into three categories: quorum-sensing inhibitors, bacterial adhesion inhibitors, and crucial virulence factor inhibitors. In this paper, the research progress of small molecule compounds against dental plaque biofilm in recent years is reviewed.

Key words: small molecule compounds, dental plaque biofilm, dental caries, periodontal diseases

ZHANG Jin, XU Xin. Research Progress of Small Molecule Compounds Against Dental Plaque Biofilm[J]. Journal of Oral Science Research, 2021, 37(3): 204-207.

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