Expressions of Bcl-2 and p53 Proteins in Gingival Hyperplasia

doi:10.13701/j.cnki.kqyxyj.2021.04.006

Abstract

Abstract: Objective: To study the expressions of Bcl-2 protein and p53 protein in gingival hyperplasia, and to explore their correlation with the anti-apoptotic mechanism of gingival hyperplasia. Methods: 11 cases of gingival hyperplasia caused by inflammation in accordance with the clinical diagnosis were selected as the experimental group and 11 cases of normal gingival tissue as the control group. The expressions of Bcl-2 and p53 proteins in the hyperplastic and normal gingival tissue were investigated by immunohistochemistry. Results: The positive expressions of Bcl-2 protein and p53 protein in hyperplastic gingival tissue were both significantly higher than those in normal gingival tissue (P<0.05). Conclusion: Bcl-2 protein and p53 protein play an important role in gingival hyperplasia, and the anti-apoptosis may involve in the pathogenesis of gingival hyperplasia.

Key words: gingival hyperplasia, anti-apoptosis, Bcl-2 protein, p53 protein

ZHANG Rui, LIU Jiaoyan, LI Dechun, ZHANG Mingzhu, PENG Yi, SHUI Yanqing. Expressions of Bcl-2 and p53 Proteins in Gingival Hyperplasia[J]. Journal of Oral Science Research, 2021, 37(4): 300-303.

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