Research Progress on Mechanisms of Drug-induced Gingival Overgrowth

doi:10.13701/j.cnki.kqyxyj.2018.04.003

Abstract

Abstract: Drug-induced gingival overgrowth (DGO) is the gingival hyperplasia and volume enlargement, which is a side effect associated with 3 types of drugs: anticonvulsants, calcium channel blockers, and immunosuppressive agents. It is characterized by some common pathological features. However, the mechanisms and clinical treatment of these disorders have not been elucidated. This review provides an overview of the pathogenesis of drug-induced gingival hyperplasia from three aspects, i.e. collagen synthesis and degradation, inflammation, and genetics, with of great importance in guiding the medical professionals to effectively prevent drug-induced gingival hyperplasia.

Key words: Drug-induced, gingival hyperplasia, Collagen, Nifedipine, Phenytoin, Cyclosporine

JIAO Xiao-Ju, ZHOU Jia, XU Shuo, JI Qiu-xia. Research Progress on Mechanisms of Drug-induced Gingival Overgrowth[J]. Journal of Oral Science Research, 2018, 34(4): 350-352.

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