Effect of Recombinant Human Epidermal Growth Factor Topical Solution Combined with Recombinant Human Granulocyte Stimulating Factor on the Treatment of Chemotherapy-induced Oral Mucositis

doi:10.13701/j.cnki.kqyxyj.2022.01.017

Abstract

Abstract: Objective: To investigate the effect of recombinant human epidermal growth factor (EGF) combined with recombinant human granulocyte stimulating factor (GSF) on oral mucositis induced by chemotherapy. Methods: A total of 94 patients with oral mucositis caused by chemotherapy admitted to our hospital from December 2019 to December 2020 were randomly divided into control group and study group, with 47 cases in each group. The control group was treated with recombinant human EGF external solution, and the study group was treated with recombinant human EGF external solution combined with GSF. Clinical efficacy, oral PH value, VAS score, serum HIF-1α, and VEGF were observed and analyzed. Results: After treatment, the clinical efficacy of the study group (95.74%) was significantly higher than that of the control group (76.60%, P<0.05). There were no significant differences in the VAS score and oral pH between two groups before treatment (P>0.05), however, after treatment, the VAS score and oral pH of the study group were lower than those of the control group (P<0.05). The serum HIF-1α level of the study group [(4.8±1.1) ng/L] was lower than that of the control group [(6.1±1.2) ng/L, P<0.05], and the VEGF level of the study group [(29.1±3.2) ng/L] was higher than that of the control group [(19.7±3.4) ng/L, P<0.05]. Conclusion: Recombinant human EGF external solution combined with GSF is effective in the treatment of oral mucositis caused by chemotherapy, which can reduce the oral PH, pain, and HIF-1α, and increase VEGF in the body.

Key words: recombinant human epidermal growth factor external solution, recombinant human granulocyte stimulating factor, oral mucositis, vascular endothelial growth factor

WANG Zhigang, ZHANG Bo. Effect of Recombinant Human Epidermal Growth Factor Topical Solution Combined with Recombinant Human Granulocyte Stimulating Factor on the Treatment of Chemotherapy-induced Oral Mucositis[J]. Journal of Oral Science Research, 2022, 38(1): 80-84.

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