Effect of Tooth Extraction on Fistula Formation in Tongue Cancer Patients Who Underwent Radical Surgery

doi:10.13701/j.cnki.kqyxyj.2022.03.007

Abstract

Abstract: Objective: To evaluate the effect of tooth extraction on fistula formation in tongue cancer patients who underwent radical surgery. Methods: The patients with tongue cancer who underwent radical surgery using an anterolateral thigh flap were recruited from January 2017 to January 2020 in the Department of Oral and Maxillofacial Surgery at the Second Xiangya Hospital. The participants were divided into 2 groups, based on whether the extraction of mandibular anterior teeth was performed with disconnecting mandible. Results: A total of 243 patients with tongue cancer were recruited, of whom 222 were male and 21 were female. The mean age of these patients was (50.38±10.21) years (rang 26 to 71). Although the incidence of experimental group(5.7%)was higher than that of control group(1.5%), no significant differences were found(P>0.05). In the Logistic regression model for the occurrence of fistula, the No. of veins anastomosis(P=0.0061), flap compromise (P<0.0001), and tooth extraction(P=0.0049) were found to be associated with fistula. Conclusion: The reserve of tooth in tongue cancer patients who underwent radical surgery with disconnecting mandible could prevent the occurrence of fistula.

Key words: fistula, tongue cancer, tooth extraction

FAN Tengfei, ZHANG Sheng, WU Hanjiang, WU Kun. Effect of Tooth Extraction on Fistula Formation in Tongue Cancer Patients Who Underwent Radical Surgery[J]. Journal of Oral Science Research, 2022, 38(3): 230-233.

References

[1] Wu K, Jiang Y, Zhou W, et al. Long noncoding RNA RC3H2 facilitates cell proliferation and invasion by targeting microRNA-101-3p/EZH2 axis in OSCC [J]. Mol Ther Nucleic Acids, 2020, 20: 97-110.
[2] Fan T, Pi H, Li M, et al. Inhibiting MT2-TFE3-dependent autophagy enhances melatonin-induced apoptosis in tongue squamous cell carcinoma [J]. J Pineal Res, 2018, 64(2).
[3] Ghantous Y, Abu Elnaaj I. Global incidence and risk factors of oral cancer[J]. Harefuah, 2017, 156(10): 645-649.
[4] 戴博文,吴汉江.舌鳞状细胞癌联合根治术式的改进及效果评价[C].上海:第一届全国口腔颌面-头颈肿瘤学术大会-聚合引领、协同发展,2019:2.
[5] Fan T, Chen Y, He Z, et al. Inhibition of ROS/NUPR1-dependent autophagy antagonises repeated cadmium exposure-induced oral squamous cell carcinoma cell migration and invasion[J]. Toxicol Lett, 2019, 314: 142-152.
[6] Szudek J, Taylor SM. Systematic review of the platysma myocutaneous flap for head and neck reconstruction[J]. Arch Otolaryngol Head Neck Surg, 2007, 133(7): 655-661.
[7] Raimondo L, Germano S, Garzaro M, et al. A technical note about flap fixation technique to prevent salivary fistulas in reconstructive oral cavity surgery[J]. J Craniofac Surg, 2014, 25(3): e280-e283.
[8] Ren ZH, Wu K, Wang Y, et al. Role of a two-step suture in the prevention of postoperative transoral salivary fistulas during reconstruction of the oral cavity[J]. Br J Oral Maxillofac Surg, 2019, 57(2): 164-168.
[9] 马春跃,朱云,郭兵,等.头颈部缺损重建术后持续性口底瘘或口咽瘘的救治性治疗[J].中国口腔颌面外科杂志,2021,19(4): 362-367.
[10] 范腾飞,叶盈希,王晴,等.以颞浅动静脉为受区血管的游离股前外侧皮瓣在上颌骨恶性肿瘤术后缺损修复中的临床应用[J].中华耳鼻咽喉头颈外科杂志,2021,56(4): 369-373.
[11] 胡砚平,贾俊.口底癌淋巴结转移与颈淋巴清扫术式选择[J].中国实用口腔科杂志,2020,13(6): 329-333.
[12] Trueman E. Management of radiotherapy-induced skin reactions[J]. Int J Palliat Nurs, 2015, 21(4):187-192.
[13] Singh M, Alavi A, Wong R, et al. Radiodermatitis: A review of our current understanding[J]. Am J Clin Dermatol, 2016, 17(3): 277-292.
[14] Patel UA, Keni SP. Pectoralis myofascial flap during salvage laryngectomy prevents pharyngocutaneous fistula[J]. Otolaryngol Head Neck Surg, 2009, 141(2):190-195.
[15] Hallock GG. Partial failure of a perforator free flap can be salvaged by a second perforator free flap[J]. Microsurgery, 2014, 34(3):177-182.
[16] Gong ZJ, Wang K, Tan HY, et al. Application of thinned anterolateral thigh flap for the reconstruction of head and neck defects[J]. J Oral Maxillofac Surg, 2015, 73(7):1410-1419.