Research Progress of Dental Protein-Repellent Resins

doi:10.13701/j.cnki.kqyxyj.2022.09.005

Abstract

Abstract: Resin materials have been widely used in oral clinical treatment for their excellent aesthetic properties and bonding properties. However, their relatively rough and hydrophobic surface is easy to absorb salivary protein and form plaque, which may cause secondary caries, periodontitis, denture stomatitis, and other diseases. In recent years, the exploration of protein-repellent resins has become a hot spot in the field of oral materials research. In this paper, their anti-adsorption mechanism, material types, and application methods are reviewed.

Key words: protein repellent, zwitterionic polymers, dental materials, resin

PENG Song, ZHANG Wu. Research Progress of Dental Protein-Repellent Resins[J]. Journal of Oral Science Research, 2022, 38(9): 819-822.

References

[1] Gad MM, Fouda SM. Current perspectives and the future of Candida albicans-associated denture stomatitis treatment [J]. Dent Med Probl, 2020, 57(1):95-102.
[2] Cao L, Wu JL, Zhang Q, et al. Novel protein-repellent and antibacterial resins and cements to inhibit lesions and protect teeth [J]. Int J Polym Sci, 2019, 2019: 11.
[3] 牟文博,程瑶,董波.苯扎氯铵改性粘接剂对牙本质-树脂远期粘接强度的影响研究[J].口腔医学研究,2021,37(4):344-348.
[4] Torres L Jr, Bienek DR. Use of protein repellents to enhance the antimicrobial functionality of quaternary ammonium containing dental materials [J]. J Funct Biomater, 2020, 11(3):54.
[5] Laschewsky A, Rosenhahn A. Molecular design of zwitterionic polymer interfaces: Searching for the difference [J]. Langmuir, 2019, 35(5):1056-1071.
[6] Mangal U, Kwon JS, Choi SH. Bio-interactive zwitterionic dental biomaterials for improving biofilm resistance: Characteristics and applications [J]. Int J Mol Sci, 2020, 21(23):9087.
[7] Li B, Jain P, Ma J, et al. Trimethylamine N-oxide-derived zwitterionic polymers: A new class of ultralow fouling bioinspired materials [J]. Sci Adv, 2019, 5(6):eaaw9562.
[8] Cheng L, Zhang K, Zhang N, et al. Developing a new generation of antimicrobial and bioactive dental resins [J]. J Dent Res, 2017, 96(8):855-863.
[9] Choi W, Jin J, Park S, et al. Quantitative interpretation of hydration dynamics enabled the fabrication of a zwitterionic antifouling surface [J]. ACS Appl Mater Interfaces, 2020, 12(7):7951-7965.
[10] Zhang N, Zhang K, Xie X, et al. Nanostructured polymeric materials with protein-repellent and anti-caries properties for dental applications [J]. Nanomaterials (Basel), 2018, 8(6):393.
[11] Zhang N, Chen C, Melo MA, et al. A novel protein-repellent dental composite containing 2-methacryloyloxyethyl phosphorylcholine [J]. Int J Oral Sci, 2015, 7(2): 103-109.
[12] Zhang N, Zhang K, Melo MA, et al. Effects of long-term water-aging on novel anti-biofilm and protein-repellent dental composite [J]. Int J Mol Sci, 2017, 18(1):186.
[13] Wang L, Xie X, Imazato S, et al. A protein-repellent and antibacterial nanocomposite for Class-V restorations to inhibit periodontitis-related pathogens [J]. Mater Sci Eng C Mater Biol Appl, 2016, 67:702-710.
[14] Mitwalli H, Balhaddad AA, Alsahafi R, et al. Novel CaF₂ nanocomposites with antibacterial function and fluoride and calcium ion release to inhibit oral biofilm and protect teeth [J]. J Funct Biomater, 2020, 11(3):56.
[15] Zhang N, Weir MD, Romberg E, et al. Development of novel dental adhesive with double benefits of protein-repellent and antibacterial capabilities [J]. Dent Mater, 2015, 31(7):845-854.
[16] Zhang N, Zhang K, Weir MD, et al. Effects of water-aging for 6 months on the durability of a novel antimicrobial and protein-repellent dental bonding agent [J]. Int J Oral Sci, 2018, 10(2):18.
[17] Xie X, Wang L, Xing D, et al. Novel dental adhesive with triple benefits of calcium phosphate recharge, protein-repellent and antibacterial functions [J]. Dent Mater, 2017, 33(5):553-563.
[18] 李爽,胡敏.关于正畸固定矫治中牙釉质脱矿的研究进展[J].口腔医学研究,2021,37(8):685-688.
[19] Park S, Wang X, Wang B, et al. The long observation in vitro of prevention effect of novel self-etching orthodontic adhesive modified with 2-methacryloxyethyl phosphorylcholine in enamel demineralization [J]. Dent Mater J, 2021, 40(3):631-640.
[20] Park SY, Yoo KH, Yoon SY, et al. Synergetic effect of 2-methacryloyloxyethyl phosphorylcholine and mesoporous bioactive glass nanoparticles on antibacterial and anti-demineralisation properties in orthodontic bonding agents [J]. Nanomaterials (Basel), 2020, 10(7):1282.
[21] Zhang N, Zhang K, Melo MA, et al. Novel protein-repellent and biofilm-repellent orthodontic cement containing 2-methacryloyloxyethyl phosphorylcholine [J]. J Biomed Mater Res B Appl Biomater, 2016, 104(5):949-959.
[22] Zhang N, Weir MD, Chen C, et al. Orthodontic cement with protein-repellent and antibacterial properties and the release of calcium and phosphate ions [J]. J Dent, 2016, 50:51-59.
[23] Bajunaid SO, Baras BH, Balhaddad AA, et al. Antibiofilm and protein-repellent polymethylmethacrylate denture base acrylic resin for treatment of denture stomatitis [J]. Materials (Basel), 2021, 14(5):1067.
[24] Kwon JS, Kim JY, Mangal U, et al. Durable oral biofilm resistance of 3D-printed dental base polymers containing zwitterionic materials [J]. Int J Mol Sci, 2021, 22(1):417.
[25] Kwon JS, Lee MJ, Kim JY, et al. Novel anti-biofouling light-curable fluoride varnish containing 2-methacryloyloxyethyl phosphorylcholine to prevent enamel demineralization [J]. Sci Rep, 2019, 9(1):1432.
[26] Kim D, Lee MJ, Kim JY, et al. Incorporation of zwitterionic materials into light-curable fluoride varnish for biofilm inhibition and caries prevention [J]. Sci Rep, 2019, 9(1):19550.
[27] Türkcani, Nalbant AD, Bat E, et al. Examination of 2-methacryloyloxyethyl phosphorylcholine polymer coated acrylic resin denture base material: surface characteristics and Candida albicans adhesion [J]. J Mater Sci Mater Med, 2018, 29(7):107.
[28] Thongthai P, Kitagawa H, Kitagawa R, et al. Development of novel surface coating composed of MDPB and MPC with dual functionality of antibacterial activity and protein repellency [J]. J Biomed Mater Res B Appl Biomater, 2020, 108(8):3241-3249.
[29] Koyama J, Fukazawa K, Ishihara K, et al. In situ surface modification on dental composite resin using 2-methacryloyloxyethyl phosphorylcholine polymer for controlling plaque formation [J]. Mater Sci Eng C Mater Biol Appl, 2019, 104:109916.
[30] Gonzalez-Bonet A, Kaufman G, Yang Y, et al. Preparation of dental resins resistant to enzymatic and hydrolytic degradation in oral environments [J]. Biomacromolecules, 2015, 16(10):3381-3388.