Nomograms to Predict the Prognosis in Locally Advanced Oral Squamous Cell Carcinoma after Curative Resection

doi:10.13701/j.cnki.kqyxyj.2023.01.011

Abstract

Abstract: Objective: To develop and validate nomograms in predicting prognosis in patients with locally advanced oral squamous cell carcinoma (OSCC) after curative resection. Methods: Two hundred and sixty-nine patients with OSCC after curative resection were assigned to the training and validation cohort. Cox regression analyses were conducted to determine the prognostic factors for overall survival (OS) and cancer specific survival (CSS), which were used to develop nomograms. Nomograms were evaluated by the concordance indicex (C-index), calibration curves, and decision curve analyses (DCA), and validated in the validation cohort. Results: Age, Kaplan-Feinstein (KFI) index, pT, the number of positive nodes, and systemic inflammatory index (SII) were significantly correlated with OS and CSS. Based on these factors, the C-index of the nomograms predicted OS and CSS in the training cohort were 0.712 and 0.709, respectively. Calibration curves exhibited good agreement between observed and predicted survival. DCA indicated the nomograms have clinical utility. These results were validated in the validation cohort. Conclusion: The nomograms can predict 3- and 5-year OS and CSS for patients with OSCC after curative resection.

Key words: oral squamous cell carcinoma, Nomogram, prognosis

JIANG Zhimin, MA Guowu, SUN Bo. Nomograms to Predict the Prognosis in Locally Advanced Oral Squamous Cell Carcinoma after Curative Resection[J]. Journal of Oral Science Research, 2023, 39(1): 56-61.

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