Abstract: Hyaluronic acid is mainly used in the field of medical beauty at present. Complications of hyaluronic acid injection often occur, however, the leading to maxillofacial space infection or even death is extremely rare. A female patient with submandibular multiple space infection caused by injection of hyaluronic acid was admitted to the Department of Oral and Maxillofacial Surgery affiliated to Kunming Medical University. After 10 days of injection of hyaluronic acid, the patient began to show signs of infection. After 40 days of injection, she was admitted to our hospital. After consultation with multidisciplinary experts, the patient was given active anti-infection treatment and symptomatic support treatment. However, the patient's condition continued to deteriorate and finally she died. In this paper, the case was reviewed and the literature was reviewed for discussion by clinicians.

Key words: hyaluronic acid injection, complication, maxillofacial multi-space infection