Expression and Prognostic Value of USP10 in Head and Neck Squamous Cell Carcinoma

doi:10.13701/j.cnki.kqyxyj.2024.05.008

Abstract

Abstract: Objective: To study the expression of USP10 and its prognostic value in head and neck squamous cell carcinoma (HNSCC). Methods: The UALCAN website was utilized to analyze the expression of USP10 mRNA and protein in HNSCC. The protein expression of USP10 was detected by immunohistochemical method in 70 HNSCC tissues and 30 normal tissues. The relationship between USP10 in HNSCC and clinical features and prognosis was analyzed. Results: The expression of USP10 was increased in HNSCC tissues (P<0.05), and the expression of USP10 was related to the degree of differentiation (P<0.05). Kaplan-Meier analysis results showed that the high USP10 expression group had a shorter survival time than the low expression group (P＜0.05). Cox regression analysis results showed that lymphatic metastasis and high USP10 expression was independent risk factors for poor prognosis in HNSCC patients (P＜0.05). Conclusion: The expression of USP10 is increased in HNSCC. USP10 may be a prognostic marker for HNSCC.

Key words: head and neck squamous cell carcinoma, USP10, prognosis

LIANG Denghuan, LIU Jiaqi, LI Donghui, ZHANG Jiajia, GUO Chaojie, ZENG Yan, XU Jiang, ZHENG Jun. Expression and Prognostic Value of USP10 in Head and Neck Squamous Cell Carcinoma[J]. Journal of Oral Science Research, 2024, 40(5): 417-421.

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