Abstract: This article reports the complete treatment process of a patient with unilateral cleft lip using a multidisciplinary approach combining clear aligner therapy with implant-prosthodontics. The patient presented with multiple clinical challenges, including dental malocclusion with poor occlusal relationship, tooth defect accompanied by insufficient three-dimensional space for implant placement, and aesthetic defects of the anterior teeth. Through the integration of clear aligner therapy and interdisciplinary collaboration between the prosthodontics and implantology departments, the aforementioned clinical issues was systematically addressed, and the aesthetic outcome of the anterior teeth was significantly improved, ultimately achieving optimal reconstruction of the occlusal relationship.

Key words: cleft lip, clear aligner orthodontic treatment, multidisciplinary management