Based on the RANKL-RANK-OPG Axis to Investigate Tanshinol’s Prevention for Alveolar Bone Osteoporosis.

Abstract

Abstract: Objective: To investigate the role of RANKL - RANK - OPG axis for tanshinol's prevention for alveolar bone osteoporosis. Methods: 24 rats were randomly divided into 3 groups: sham-ovariectomized rats, ovariectomized rats and ovariectomized rats with tanshinol treatment. After 90 days alveolar bone were dislodged to observe alveolar bone tissue morphology change. Histochemical staining was used to detect the activity of the TRAP in the alveolar bone tissue. Immunohistochemical staining was used to detect the expression of RANKL and OPG in alveolar bone tissue. Results: Compared with ovariectomized rats, alveolar bone mass increased, the number of TRAP positive osteoclast and the ratio of RANKL/OPG decreased. Conclusion: Tanshinol may regulate the RANKL - RANK - OPG axis to prevent alveolar bone osteoporosis.

Key words: Alveolar bone , Osteoporosis, Tanshinol, RANKL, OPG

CLC Number:

R782

ZHANG Xiao-yan, CUI Liao, WU Tie.. Based on the RANKL-RANK-OPG Axis to Investigate Tanshinol’s Prevention for Alveolar Bone Osteoporosis.[J]. Journal of Oral Science Research, 2015, 31(6): 588-590.

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