Abstract: Objective: To investigate the effects of butorphanol combined with Tetracaine Hydrochloride Jelly on catheter-related bladder discomfort. Methods: Ninety male patients undergoing selective maxillofacial plastic surgery were selected and divided into three groups. In group A, paraffin oil was used to daub the front end of catheter. In group B and group C, Tetracaine Hydrochloride Jelly was used to daub the front end of catheter. Meanwhile, in group C, butorphanol (20 μg/kg) was intravenously injected ten minutes before the end of operation. MAP, HR and SpO₂ were recorded at 0, 1, 2, 3, 6 hours after tracheal estuation. Agitation and urinary tract irritation in awakening period of patients were also recorded. Results: The incidence and scores of CRBD at 0h and 1h after tracheal extubation were significantly lower in group B than group A (P<0.05), and those indexes in group C was the lowest (P<0.05). Conclusion: Combination of butorphanol and Tetracaine Hydrochloride Jelly injected into the urethral of male patients during general anesthesia can reduce the CRBD at tracheal extubation immediately and 1 hour after tracheal extubation.

Key words: Butorphanol, Tetracaine hydrochloride jelly, Catheter-related bladder discomfort