Research Progress of Gene Therapy on Osteoarthrosis.

doi:10.13701/j.cnki.kqyxyj.2018.03.004

Abstract

Abstract: Osteoarthrosis is a common degenerative joint disease, which is characterized by cartilage injury. Temporomandibular joint osteoarthrosis is a common oral and maxillofacial disease, its repair and treatment are quite challenging job to clinical and scientific researchers. It is a lot of treatment of this disease, but the effect is not satisfactory. Gene therapy is a new treatment technology developed in recent years, which involves the target cell, gene, carrier and so on. This article summarized the current literature on gene therapy of osteoarthrosis.

Key words: Osteoarthrosis, Gene therapy, Temporomandibular joint

CUI Shi-man, ZHANG Qing-bin. Research Progress of Gene Therapy on Osteoarthrosis.[J]. Journal of Oral Science Research, 2018, 34(3): 229-232.

References

[1] Madry H, Cucchiarini M. Gene therapy for human osteoarthritis: principles and clinical translation, 2016, 16(3)∶331-346
[2] 马绪臣,张震康.颞下颌关节紊乱病的命名、诊断分类及治疗原则[J].中华口腔医学杂志,2002,37(4)∶241-243
[3] Demange MK, Sisto M, Rodeo S. Future trends for unicompartmental arthritis of the knee: Injectables and & stem cells. Clinics in sports medicine, 2014 , 33(1)∶161-174
[4] Hung GL, Galea-Lauri J, Mueller GM, et al. Suppression of intra-articular responses to interleukin-1 by transfer of the interleukin -1 receptor antagonist gene to synovium [J]. Gene Ther, 1994, 1(1)∶64-69
[5] CH Jo, YG Lee, WH Shin, et al. Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial [J]. Stem cells, 2014, 32(5)∶1254-1266
[6] K Chen, C Man, B Zhang, et al. Effect of in vitro chondrogenic differentiation of autologous mesenchymal stem cells on cartilage and subchondral cancellous bone repair in osteoarthritis of temporomandibular joint [J]. Int J Oral Maxillofac Surg, 2013, 42(2)∶240-248
[7] Steinert AF, Weissenberger M, Kunz M,et al. Indian hedgehog gene transfer is a chondrogenic inducer of human mesenchymal stem cells [J]. Arthritis Res Ther,2012,14(4)∶R168
[8] Gabner S, Hlavaty J, Velde K. Inflammation-induced transgene expression in genetically engineered equine mesenchymal stem cells [J]. J Gene Med, 2016(8)∶154-164
[9] MF Pittenger, AM Mackay, SC Beck, et al. Multilineage potential of adult human mesenchymal stem cells [J]. Science, 1999, 284(5411)∶143-147
[10] 杨兴华,彭琳,刘云生,等.骨髓间充质干细胞移植治疗颞下颌关节骨关节病[J].中国组织工程研究,2013(19)∶3488-3494
[11] Shi S, Mercer S. Growth factor transgenes interactively regulate articular chondrocytes [J]. J Cell Biochemistry, 2013, 114(4)∶908-919
[12] Rey-Rico A, Frisch J, Schmitt G, et al. PEO-PPO-PEO carriers for rAAV-mediated transduction of human articular chondrocytes in vitro and in a human osteochondral defect model [J]. ACS Appl Master Interfaces, 2016, 8(32)∶20600-20613
[13] Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells [J]. Mol Biol Cell, 2002, 13∶4279-4295
[14] Yoon IS, Chung CW, Sung JH, et al. Proliferation and chondrogenic differentiation of human adipose-derived mesenchymal stem cells in porous hyaluronic acid scaffold [J]. J Biosci Bioeng, 2011,112∶402-408
[15] Zhang P, Zhong ZH, Yu HT, et al. Exogenous expression of IL-1a and TGF-β1 promotes in vivo repair in experimental rabbit osteoarthritis [J]. Scand J Rheumatol, 2015, 44(5)∶404-411
[16] Shi S, Mercer S, Eckert GJ, et al. Growth factor regulation of growth factor production by multiple gene transfer to chondrocytes [J]. Growth Factors, 2013, 31(1)∶32-38
[17] Madry H, Kaul G, David Zurakowski, et al.Cartilage constructs engineered from chondrocytes Overexpressing IGF-1 improved the repair of osteochondral defects in a rabbit model [J]. Eur Cell Master, 2013, 25∶229-247
[18] Cucchiarini M, Ekici M, Schetting, et al. Metabolic activities and chondrogenic differentiation of human mesenchymal stem cells following recombinant adeno-associated virus-mediated gene transfer and overexpression of fibroblast growth factor 2 [J]. Tissue Engineering Part A,2011,17∶1921-1933
[19] Carreira AC, Lojudice FH, Halcsik E, et al. Bonemorphogenetic proteins:facts, challenges, and Future respectives [J]. J Dent Res, 2014, 93∶335-345
[20] Che JH, Zhang ZR, Li GZ, et al. Application of tissue engineered cartilage with BMP-7gene to repair knee jointcartilage injury in rabbits [J]. Knee Surg Sports Traumatol Arthrosc, 2010, 18(4)∶496-503
[21] 邓末宏,孟庆功,龙星. β1型整合素在兔颞下颌关节骨关节病组织中的表达变化[J].口腔医学研究,2011,27(7)∶564-567
[22] Garza-Veloz I, Romero-Diaz VJ, Martinez-Fierro, et al. Analyses of chondrogenic induction of adipose mesenchymal stem cells by combined co-stimulation mediated by adenoviral gene transfer [J]. Arthritis Res Ther, 2013, 15(4)∶R80
[23] Pisal DS, Kosloski MP, Balu-Iyer SV. Delivery of therapeutic proteins [J]. Pharm Sci, 2010, 99(6)∶2557-2575
[24] Yao Y, Zhang F, Pang PX, et al. In vitro study of chondrocyte redifferentiation with lentiviral vector-mediated transgenic TGF-3 and shRNA suppressing type I collagen in three-dimensional culture [J]. J Tissue Eng Regen Med, 2011, 5(8)∶219-227
[25] Hemphill DD, Mcllwraith CW, Slaycten RA, et al. Adeno-associated virus gene therapy vector scAAVIGF-1 for transduction of equine articular chondrocytes and DNA-seq analysis [J]. Osteoarthritis cartilage, 2016, 24(5)∶902-911
[26] Rekha MR, Sharma CP. Polymers for gene delivery: current status and future perspectives [J]. Recent Patents on DNA & Gene Sequences, 2012,6(2)∶98-107
[27] Zhao J,Fan X, Zhang Q, et al. Chitosan-plasmid DNA nanoparticles encoding small hairpin RNA targeting MMP-3 and-13 to inhibit the expression of dedifferentiation related genes in expanded chondrocytes [J]. J Biomed Mater Res A, 2014,102(2)∶373-380
[28] Sukarto A, Yu C, Flynn LE, et al. Co-delivery of adipose-derived stem cells and growth factor-loaded microspheres in RGD-grafted N-methacrylate glycol chitosan gels for focal chondral repair [J]. Biomacromolecules,2012,13(8)∶2490-2502