Effect of Orthodontic Treatment on Levels of MMP-2 and TIMP-2 in Gingival Crevicular Fluids of Malocclusion Patients.

doi:10.13701/j.cnki.kqyxyj.2018.05.020

Abstract

Abstract: Objective: To analyze the effect of orthodontic treatment on the levels of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of tissue inhibitors of metalloproteinases-2 (TIMP-2) in gingival crevicular fluids of patients with malocclusion. Methods: Sixty cases of malocclusion treated in the hospital were selected, which were divided into group A, B, C, and D according to the random number table method (n=15). All patients were treated with orthodontic treatment, who were given 0, 50, 150, and 250 g of distal movement initial force, respectively. The level and ratio of MMP-2 and TIMP-2 in gingival crevicular fluids before and 1, 2, 3 and 4 weeks after treatment were compared. Results: After treatment for 1, 2, 3, and 4 weeks, the levels of MMP-2 and TIMP-2 in group B and C were significantly higher than those in group A and D. And the levels of MMP-2 and TIMP-2 in group C were significantly higher than those in group B (P<0.05). The MMP-2/TIMP-2 ratios of gingival crevicular fluid in group B and C were significantly increased after 1 week, however, little decreased after 2, 3, and 4 weeks. There were no significant difference in the levels of MMP-2 and TIMP-2 in group A and D before and after treatment. Conclusion: The levels of MMP-2 and TIMP-2 in gingival crevicular fluid are related to the size and duration of orthodontic force, and the dynamic levels of MMP-2 and TIMP-2 in gingival crevicular fluid can be used as an important reference index to analyze the orthodontic tooth augmentation.

Key words: Malocclusion, Orthodontic treatment, Matrix metalloproteinase-2, Tissue inhibitors of metalloproteinases-2

XIONG Ya-fang, ZHU Ni-man, YANG Fang. Effect of Orthodontic Treatment on Levels of MMP-2 and TIMP-2 in Gingival Crevicular Fluids of Malocclusion Patients.[J]. Journal of Oral Science Research, 2018, 34(5): 544-547.

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