Research Progress on Central Regulation Mechanism of Dental Pulp Inflammatory Pain

doi:10.13701/j.cnki.kqyxyj.2023.01.003

Abstract

Abstract: Pain is the main reason why children refuse to cooperate with treatment when seeing a doctor. How to reduce pain, avoid dental anxiety, and improve the rate of cooperation in diagnosis and treatment is a great challenge for pediatric dentists. Pulpitis is one of the most common oral diseases that cause toothache. The conduction pathway of toothache is that C fiber and Aδ fiber in pulp nerve transmit stimulation to trigeminal ganglion (TG), and further to the central nervous system. Anatomical studies have confirmed that trigeminal spinal subnucleus caudalis (Ⅴc), also known as the medullary dorsal horn (MDH), receives projections from primary afferent fibers of dental pulp and plays an important role in pain transmission. This paper reviews the relevant literature on dental pulp inflammatory pain in recent years, and summarizes the role of neurons and microglia in pain regulation in Ⅴc, which aims to look for more therapeutic targets for dental pulp inflammatory pain.

Key words: pulpitis, pain, central, trigeminal spinal subnucleus caudalis, medullary dorsal horn

WANG Yanqi, SUN Shukai. Research Progress on Central Regulation Mechanism of Dental Pulp Inflammatory Pain[J]. Journal of Oral Science Research, 2023, 39(1): 15-19.

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