Research Advances in Relationship between Mitochondria and Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells

doi:10.13701/j.cnki.kqyxyj.2023.01.002

Abstract

Abstract: Bone marrow mesenchymal stem cells (BMSCs) are widely used in bone tissue engineering and regenerative medicine due to their high potential for differentiation and availability. However, difficult to control the differentiation direction of transplanted BMSCs is a major problem in stem cell therapy. Mitochondria are essential organelles of most eukaryotic cells. The differentiation of BMSCs is accompanied by dynamic changes of mitochondria, including morphology, distribution, number, dynamics, and metabolic transformation. Meanwhile, studies show that mitochondria are indispensable in determining BMSCs differentiation fate. Therefore, exploring the relationship between mitochondria and osteogenic differentiation fate of BMSCs is significant for the treatment of bone related diseases. In this review, we report recent advances on the function of mitochondria in BMSCs osteogenic differentiation and the potential strategies for mitochondrial targeted therapy in regenerative medicine and bone repair, promising to broaden therapeutic options of bone tissue engineering and regenerative medicine.

Key words: bone marrow mesenchymal stem cells, osteogenesis, mitochondrial, bone engineering

LI Chen, GAN Xueqi. Research Advances in Relationship between Mitochondria and Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells[J]. Journal of Oral Science Research, 2023, 39(1): 11-14.

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