Research Progress on PDGF/PDGFRβ Pathway Coupling with Osteogenesis and Angiogenesis

doi:10.13701/j.cnki.kqyxyj.2022.02.004

Abstract

Abstract: Osteogenesis and angiogenesis are indispensable to development and regeneration of bone, and their coupling is a crucial factor in bone formation. Platelet-derived growth factor receptor beta (PDGFRβ) belongs to the class Ⅲ receptor tyrosine kinase, which participates in a variety of physiological activities in cells and tissues through the downstream signal cascade, after the combination with corresponding platelet-derived growth factors (PDGFs). With broader studies on tissue engineering and regenerative medicine, the participation of such pathway in the regulation of activities of microvascular system and osteoblast lineage has been founded by various scholars, indicating that PDGF/PDGFRβ pathway plays an important role in the coupling of osteogenesis and angiogenesis.

Key words: PDGF, PDGFRβ, osteogenesis, angiogenesis

SU Han, TANG Guohua. Research Progress on PDGF/PDGFRβ Pathway Coupling with Osteogenesis and Angiogenesis[J]. Journal of Oral Science Research, 2022, 38(2): 113-115.

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