Research Progress of Porphyromonas Gingivalis Promoting Cardiovascular Disease

doi:10.13701/j.cnki.kqyxyj.2022.02.003

Abstract

Abstract: Chronic periodontitis and cardiovascular disease are two common chronic inflammatory diseases in today's society, which are affected by a variety of risk factors. Epidemiological investigations found that chronic periodontitis is closely related to increased cardiovascular disease risk. Porphyromonas gingivalis colonized in the gingival sulcus of chronic periodontitis patients could invade cardiovascular tissues through bacteremia and phagocyte-mediated pathways and secrete virulence factors. By triggering endotoxemia, endothelial dysfunction, oxidative stress, foam cell formation and lipid accumulation, vascular remodeling, plaque rupture and thrombosis, it leads to serious cardiovascular end-events. The study on the specific ways that Porphyromonas gingivalis affects cardiovascular disease provides a new method for the prevention and treatment of cardiovascular disease, thereby reducing the burden of disease in society.

Key words: chronic periodontitis, Porphyromonas gingivalis, cardiovascular disease, antherosclerosis, systematic inflammation

WU Qinrui, PENG Xian. Research Progress of Porphyromonas Gingivalis Promoting Cardiovascular Disease[J]. Journal of Oral Science Research, 2022, 38(2): 108-112.

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