Effects of Porphyromonas Gingivalis Infection on Placental Tissue and Birth Weight of Neonates in Rats.

doi:10.13701/j.cnki.kqyxyj.2018.05.009

Abstract

Abstract: Objective: To investigate the effects of Porphyromonas gingivalis infection on expressions of placental Fas ligand (Fas L), Toll-like receptor (TLR)2 and TLR4, and birth weight of neonates in rats. Methods: Female rats were randomly divided into 3 groups: P.gingivalis-infected group, negative control group, and blank control group (n=13 for each group). Murine model of P.gingivalis infection was established by the tail vein injection. Birth weight of every neonate and litter weights was recorded, and the placentas were obtained at gestational day of 18. The expression levels of placental Fas, FasL, TLR2, and TLR4 were detected by Western blot analysis and immunohistochemical staining. Results: The newborn rats showed significantly lower birth weight in P.gingivalis-infected group. Furthermore, Fas, FasL, and TLR4 in placental tissues were significantly increased following P.gingivalis infection. However, the expression of TLR2 had no significant difference between P.gingivalis-infected group and negative control group. Conclusion: In our murine model, with elevated expression of Fas, FasL and TLR4 in placenal tissues, P.gingivalis infection induces lower birth weight of neonates. The results indicate that pregnant woman suffering from periodontal disease, with delivery of low birth weight babies, might be related to P.gingivalis-induced abnormally regulation of placental Fas, FasL and TLR4.

Key words: Porphyromonas gingivalis, Preterm low birth weight, Placenta

LIANG Shan-shan, XING Wen-yan, JI Yao-ting, JIANG Han, DU Min-quan. Effects of Porphyromonas Gingivalis Infection on Placental Tissue and Birth Weight of Neonates in Rats.[J]. Journal of Oral Science Research, 2018, 34(5): 495-499.

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